polenovjournalРоссийский нейрохирургический журнал имени профессора А. Л. ПоленоваRussian Neurosurgical Journal named after Professor A. L. Polenov2071-2693Семинары, Конференции и Форумы10.56618/20712693_2022_14_3_140polenovjournal-140Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWS OF LITERATUREНаправления возможного использования графена в неврологии и нейрохирургииDirections of possible use of graphene in neurology and neurosurgeryhttps://orcid.org/0000-0002-4830-907XВоробьевС. В.VorobevS. V.

Воробьев Сергей Владимирович

Аккуратова ул., 2, Санкт-Петербург, 197341; Политехническая ул., 26, Санкт-Петербург, 194021; Литовская ул., 2, Санкт-Петербург, 194100

Vorobev Sergej Vladimirovich

Akkuratova st., 2, Saint-Petersburg, 197341; Politekhnicheskaya st., 26, Saint Petersburg, 194021; Litovskaya st. 2, Saint Petersburg, 194100

https://orcid.org/0000-0002-0074-4021ТерновыхК. И.TernovyhI. K.

Терновых Иван Константинович

Аккуратова ул., 2, Санкт-Петербург, 197341; Политехническая ул., 26, Санкт-Петербург, 194021

Ternovyh Ivan Konstantinovich

Akkuratova st., 2, Saint-Petersburg, 197341; Politekhnicheskaya st., 26, Saint Petersburg, 194021

https://orcid.org/0000-0003-0829-5053ЛебедевА. А.LebedevА. А.

Лебедев Александр Александрович

Политехническая ул., 26, Санкт-Петербург, 194021 

Lebedev Aleksandr Aleksandrovich

Politekhnicheskaya st., 26, Saint Petersburg, 194021

https://orcid.org/0000-0001-9709-5138СмирновА. Н.SmirnovA. N.

Смирнов Александр Николаевич

Политехническая ул., 26, Санкт-Петербург, 194021 

Smirnov Aleksandr Nikolaevich

Politekhnicheskaya st., 26, Saint Petersburg, 194021

https://orcid.org/0000-0002-5320-3632УсиковА. С.UsikovA. S.

Усиков Александр Сергеевич

Политехническая ул., 26, Санкт-Петербург, 194021; Энгельса пр., 27/5А, Санкт-Петербург, 194156

Usikov Aleksandr Sergeevich

Politekhnicheskaya st., 26, Saint Petersburg, 194021; Engels Avenue, 27/5A, Saint Petersburg, 194156

https://orcid.org/0000-0002-5078-1322ЛебедевС. П.LebedevS. P.

Лебедев Сергей Петрович

Политехническая ул., 26, Санкт-Петербург, 194021

Lebedev Sergej Petrovich

Politekhnicheskaya st., 26, Saint Petersburg, 194021

ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» МЗ РФ; ФГБУН «Физико-технический институт имени А.Ф. Иоффе» Минобрнауки России; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» МЗ РФРоссияAlmazov National Medical Research Centre; Ioffe Institute; Saint-Petersburg State Pediatric Medical UniversityRussian FederationФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» МЗ РФ; ФГБУН «Физико-технический институт имени А.Ф. Иоффе» Минобрнауки РоссииРоссияAlmazov National Medical Research Centre; Ioffe InstituteRussian FederationФГБУН «Физико-технический институт имени А.Ф. Иоффе» Минобрнауки РоссииРоссияIoffe InstituteRussian FederationФГБУН «Физико-технический институт имени А.Ф. Иоффе» Минобрнауки России; ООО «Нитридные кристаллы — Алюминий-Н»РоссияIoffe Institute; Nitride Crystals Aluminum-NRussian Federation202208082024143140145Copyright © Воробьев С.В., Терновых К.И., Лебедев А.А., Смирнов А.Н., Усиков А.С., Лебедев С.П., 20242024Воробьев С.В., Терновых К.И., Лебедев А.А., Смирнов А.Н., Усиков А.С., Лебедев С.П.Vorobev S.V., Ternovyh I.K., Lebedev А.А., Smirnov A.N., Usikov A.S., Lebedev S.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://polenovjournal.elpub.ru/jour/article/view/140

В настоящее время наблюдается широкое внедрение в клиническую практику инновационных методик с использованием нанотехнологий. Одним из перспективных материалов, представляющих научно-практический интерес для медицинской науки, является графен — аллотропная модификация углерода, обладающая рядом специфических физических свойств. Нами проведен анализ результатов исследований по данной проблеме. Имеющиеся в литературе сведения говорят о высоких перспективах его использования в нейронауках. Установлены основные направления внедрения графена в неврологию и нейрохирургию. Разработка технологических приемов с использованием графена будет способствовать появлению новых эффективных методов диагностики и терапии, качественно повышающих уровень ведения пациентов с заболеваниями и травмами нервной системы.

Currently, there is a widespread introduction into clinical practice of innovative techniques using nanotechnology. One of the promising materials of scientific and practical interest for medical science is graphene, an allotropic modification of carbon with a number of specific physical properties. We have analyzed the results of research on this problem. The information available in the literature indicates high prospects for its use in neuroscience. The main directions of graphene introduction into neurology and neurosurgery have been established. The development of technological techniques using graphene will contribute to the emergence of new effective methods of diagnosis and therapy, qualitatively increasing the level of management of patients with diseases and injuries of the nervous system.

графенболезнь Альцгеймеранейроонкологиябета-амилоидбиологические сенсорынаноплатформыgrapheneAlzheimer’s diseaseneurooncologybeta-amyloidbiological sensorsnanoplatformsРабота поддержана грантом РНФ № 22‑12‑00134.The work was supported by the grant of the Russian Science Foundation No. 22‑12‑00134.ReferencesDrowart J., De Maria G., Inghram M. G. Thermodynamic Study of SiC Utilizing a Mass Spectrometer. J. Chem. Phys. 1958;29:1015–1021. https://doi.org/10.1063/1.1744646Drowart J., De Maria G., Inghram M. G. Thermodynamic Study of SiC Utilizing a Mass Spectrometer. J. Chem. Phys. 1958;29:1015–1021. https://doi.org/10.1063/1.1744646Lebedev S. P., Amel’chuk G., Eliseyev I. A., Nikitina I. P., Dementev P. A., Zubov A. V., Lebedev A. A. Comparison of graphene films grown on 6h-sic and 4h-sic substrates. Fullerenes, Nanotubes and Carbon Nanostructures. 2020;28(4): 321–324. https://doi.org/10.1080/1536383X.2019.1697684Lebedev S. P., Amel’chuk G., Eliseyev I. A., Nikitina I. P., Dementev P. A., Zubov A. V., Lebedev A. A. Comparison of graphene films grown on 6h-sic and 4h-sic substrates. Fullerenes, Nanotubes and Carbon Nanostructures. 2020;28(4): 321–324. https://doi.org/10.1080/1536383X.2019.1697684Давыдов В.Ю., Усачёв Д.Ю., Лебедев С.П., Смирнов А.Н., Левицкий В.С., Елисеев И.А., Алексеев П.А., Дунаевский М.С., Вилков О.Ю., Рыбкин А.Г., Лебедев А.А. Исследование кристаллической и электронной структуры графеновых пленок, выращенных на 6h-sic (0001) Физика и техника полупроводников. 2017;(51/8):1116–1124. https://doi.org/10.21883/FTP.2017.08.44800.8559.Давыдов В.Ю., Усачёв Д.Ю., Лебедев С.П., Смирнов А.Н., Левицкий В.С., Елисеев И.А., Алексеев П.А., Дунаевский М.С., Вилков О.Ю., Рыбкин А.Г., Лебедев А.А. Исследование кристаллической и электронной структуры графеновых пленок, выращенных на 6h-sic (0001) Физика и техника полупроводников. 2017;(51/8):1116–1124. https://doi.org/10.21883/FTP.2017.08.44800.8559.Воробьев С.В., Янишевский С.Н., Емелин А.Ю., Лебедев А.А., Лебедев С.П., Макаров Ю.Н., Усиков А.С., Клотченко С.А., Васин А.В. Перспективы применения биологических сенсоров на основе графена в ранней диагностике болезни Альцгеймера (обзор литературы). Клиническая лабораторная диагностика. 2022;67(1):5–12. https://doi.org/10.51620/086920842022671512Vorobev S. V., Yanishevskij S.N., Emelin A. Yu., Lebedev A. A., Lebedev S. P., Makarov Yu.N., Usikov A. S., Klotchenko S. A., Vasin A. V. Prospects for the use of graphene-based biological sensors in the early diagnosis of Alzheimer's disease (literature review). Klinicheskaya laboratornaya diagnostika 2022;67(1):5–12. (In Russ.)Georgakilas V., Otyepka M., Bourlinos A.B., Chandra V., Kim N., Kemp K.C., Hobza P., Zboril R., Kim K.S. Functionalization of graphene: covalent and non-covalent approaches, derivatives and applications. Chem. Rev. 2012;112:6156–6214. https://doi.org/10.1021/cr3000412.Georgakilas V., Otyepka M., Bourlinos A.B., Chandra V., Kim N., Kemp K.C., Hobza P., Zboril R., Kim K.S. Functionalization of graphene: covalent and non-covalent approaches, derivatives and applications. Chem. Rev. 2012;112:6156–6214. https://doi.org/10.1021/cr3000412.Tehrani Z., Burwell G., Mohd Azmi M. A., Castaing A., Rickman R., Almarashi J., Dunstan P., Miran Beigi A., Doak S.H., Guy O. J. Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker. 2D Materials. 2014;1(025004):1–19. https://doi.org/10.1088/2053–1583/1/2/025004Tehrani Z., Burwell G., Mohd Azmi M. A., Castaing A., Rickman R., Almarashi J., Dunstan P., Miran Beigi A., Doak S.H., Guy O. J. Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker. 2D Materials. 2014;1(025004):1–19. https://doi.org/10.1088/2053–1583/1/2/025004Лебедев А. А., Давыдов В.Ю., Новиков С.Н., Литвин Д.П., Макаров Ю. Н., Климович В. Б., Самойлович М. П. Биосенсоры на основе графена. Письма в журнал технической физики. 2016;42(14):28–35.Lebedev A. A., Davydov V. Yu., Novikov S. N., Litvin D. P., Makarov Yu.N., Klimovich V. B., Samojlovich M. P. Graphene-based biosensors. Pis’ma v zhurnal tekhnicheskoj fiziki. 2016;42(14):28–35. (In Russ.)Smith A. D., Elgammal K., Niklaus F., Delin A., Fischer A.C., Vaziri S., Forsberg F., Råsander M., Hugosson H., Bergqvist L., Schröder S., Kataria S., Östlinga M., Lemme M.C., Resistive graphene humidity sensors with rapid and direct electrical readout. Nanoscale. 2015;7:19099. https://doi.org/10.1039/C5NR06038ASmith A. D., Elgammal K., Niklaus F., Delin A., Fischer A.C., Vaziri S., Forsberg F., Råsander M., Hugosson H., Bergqvist L., Schröder S., Kataria S., Östlinga M., Lemme M.C., Resistive graphene humidity sensors with rapid and direct electrical readout. Nanoscale. 2015;7:19099. https://doi.org/10.1039/C5NR06038ALebedev S., Usikov A., Novikov S., Shabunina E., Schmidt N., Barash I., Roenkov A., Lebedev A., Makarov Y., Graphene/SiC functionalization for blood type sensing applications. Materials Science Forum. 2018;924:909. https://doi.org/3.4028/www.scientific.net/MSF.924.909Lebedev S., Usikov A., Novikov S., Shabunina E., Schmidt N., Barash I., Roenkov A., Lebedev A., Makarov Y., Graphene/SiC functionalization for blood type sensing applications. Materials Science Forum. 2018;924:909. https://doi.org/3.4028/www.scientific.net/MSF.924.909Iannazzo D., Espro C., Celesti C., Ferlazzo A., Neri G. Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots. Cancers (Basel). 2021;13(13):3194. https://doi.org/10.3390/cancers13133194Iannazzo D., Espro C., Celesti C., Ferlazzo A., Neri G. Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots. Cancers (Basel). 2021;13(13):3194. https://doi.org/10.3390/cancers13133194Chen S. L., Chen C. Y., Hsieh J.C., Yu Z. Y., Cheng S. J., Hsieh K. Y., Yang J. W., Kumar P. V., Lin S.F., Chen G. Y. Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis. Nanomaterials (Basel). 2019;9(12):1725. https://doi.org/10.3390/nano9121725Chen S. L., Chen C. Y., Hsieh J.C., Yu Z. Y., Cheng S. J., Hsieh K. Y., Yang J. W., Kumar P. V., Lin S.F., Chen G. Y. Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis. Nanomaterials (Basel). 2019;9(12):1725. https://doi.org/10.3390/nano9121725Safarzadeh M., Suhail A., Sethi J., Sattar A., Jenkins D., Pan G. A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation. Nanomaterials (Basel). 2021;11(4):985. https://doi.org/10.3390/nano11040985Safarzadeh M., Suhail A., Sethi J., Sattar A., Jenkins D., Pan G. A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation. Nanomaterials (Basel). 2021;11(4):985. https://doi.org/10.3390/nano11040985Liu X., Lin L. Y., Tseng F. Y., Tan Y.C., Li J., Feng L., Song L., Lai C. F., Li X., He J. H., Sakthivel R., Chung R. J. Label-free electrochemical immunosensor based on gold nanoparticle/polyethyleneimine/reduced graphene oxide nanocomposites for the ultrasensitive detection of cancer biomarker matrix metalloproteinase 1. Analyst. 2021;146(12):4066–4079. https://doi.org/10.1039/d1an00537eLiu X., Lin L. Y., Tseng F. Y., Tan Y.C., Li J., Feng L., Song L., Lai C. F., Li X., He J. H., Sakthivel R., Chung R. J. Label-free electrochemical immunosensor based on gold nanoparticle/polyethyleneimine/reduced graphene oxide nanocomposites for the ultrasensitive detection of cancer biomarker matrix metalloproteinase 1. Analyst. 2021;146(12):4066–4079. https://doi.org/10.1039/d1an00537eYu D., Yin Q., Wang J., Yang J., Chen Z., Gao Z., Huang Q., Li S. SERS-Based Immunoassay Enhanced with Silver Probe for Selective Separation and Detection of Alzheimer’s Disease Biomarkers. Int J Nanomedicine. 2021;16:1901–1911. https://doi.org/10.2147/IJN.S293042Yu D., Yin Q., Wang J., Yang J., Chen Z., Gao Z., Huang Q., Li S. SERS-Based Immunoassay Enhanced with Silver Probe for Selective Separation and Detection of Alzheimer’s Disease Biomarkers. Int J Nanomedicine. 2021;16:1901–1911. https://doi.org/10.2147/IJN.S293042Dey J., Roberts A., Mahari S., Gandhi S., Tripathi P. P. Electrochemical Detection of Alzheimer's Disease Biomarker, β-Secretase Enzyme (BACE 1), With One-Step Synthesized Reduced Graphene Oxide. Front Bioeng Biotechnol. 2022;10:873811. https://doi.org/10.3389/fbioe.2022.873811Dey J., Roberts A., Mahari S., Gandhi S., Tripathi P. P. Electrochemical Detection of Alzheimer's Disease Biomarker, β-Secretase Enzyme (BACE 1), With One-Step Synthesized Reduced Graphene Oxide. Front Bioeng Biotechnol. 2022;10:873811. https://doi.org/10.3389/fbioe.2022.873811Sun L., Zhong Y., Gui J., Wang X., Zhuang X., Weng J. A hydrogel biosensor for high selective and sensitive detection of amyloidbeta oligomers. Int J Nanomedicine. 2018;13:843–856. https://doi.org/10.2147/IJN.S152163Sun L., Zhong Y., Gui J., Wang X., Zhuang X., Weng J. A hydrogel biosensor for high selective and sensitive detection of amyloidbeta oligomers. Int J Nanomedicine. 2018;13:843–856. https://doi.org/10.2147/IJN.S152163Zhu D., Liu B., Wei G. Two-Dimensional Material-Based Colorimetric Biosensors: A Review. Biosensors (Basel). 2021;11(8):259. https://doi.org/10.3390/bios11080259Zhu D., Liu B., Wei G. Two-Dimensional Material-Based Colorimetric Biosensors: A Review. Biosensors (Basel). 2021;11(8):259. https://doi.org/10.3390/bios11080259Park D., Lee D., Kim H. J., Yoon D. S., Hwang K. S. Scalable Functionalization of Polyaniline-Grafted rGO Field-Effect Transistors for a Highly Sensitive Enzymatic Acetylcholine Biosensor. Biosensors (Basel). 2022;12(5):279. https://doi.org/10.3390/bios12050279Park D., Lee D., Kim H. J., Yoon D. S., Hwang K. S. Scalable Functionalization of Polyaniline-Grafted rGO Field-Effect Transistors for a Highly Sensitive Enzymatic Acetylcholine Biosensor. Biosensors (Basel). 2022;12(5):279. https://doi.org/10.3390/bios12050279Nichols J. W., Bae Y.H. Odyssey of a cancer nanoparticle: from injection site to site of action. Nano Today. 2012;7(6):606–618. https://doi.org/10.1016/j.nantod.2012.10.010Nichols J. W., Bae Y.H. Odyssey of a cancer nanoparticle: from injection site to site of action. Nano Today. 2012;7(6):606–618. https://doi.org/10.1016/j.nantod.2012.10.010Patel S.C., Lee S., Lalwani G., Suhrland C., Chowdhury SM, Sitharaman B. Graphene-based platforms for cancer therapeutics. Ther Deliv. 2016;7(2):101–16. https://doi.org/10.4155/tde.15.93Patel S.C., Lee S., Lalwani G., Suhrland C., Chowdhury SM, Sitharaman B. Graphene-based platforms for cancer therapeutics. Ther Deliv. 2016;7(2):101–16. https://doi.org/10.4155/tde.15.93Moore T. L., Podilakrishna R., Rao A., Alexis F. Systemic administration of polymer-coated nano-graphene to deliver drugs to glioblastoma. Part. and Part. Syst. Char. 2014;31(8):886–894. 1 https://doi.org/0.1002/ppsc.201300379Moore T. L., Podilakrishna R., Rao A., Alexis F. Systemic administration of polymer-coated nano-graphene to deliver drugs to glioblastoma. Part. and Part. Syst. Char. 2014;31(8):886–894. 1 https://doi.org/0.1002/ppsc.201300379Kutwin M., Sosnowska M. E., Strojny-Cieślak B., Jaworski S., Trzaskowski M., Wierzbicki M., Chwalibog A., Sawosz E. MicroRNA Delivery by Graphene-Based Complexes into Glioblastoma Cells. Molecules. 2021;26(19):5804. https://doi.org/10.3390/molecules26195804Kutwin M., Sosnowska M. E., Strojny-Cieślak B., Jaworski S., Trzaskowski M., Wierzbicki M., Chwalibog A., Sawosz E. MicroRNA Delivery by Graphene-Based Complexes into Glioblastoma Cells. Molecules. 2021;26(19):5804. https://doi.org/10.3390/molecules26195804Campbell E., Hasan M.T., Pho C., Callaghan K., Akkaraju G. R., Naumov A. V. Graphene Oxide as a Multifunctional Platform for Intracellular Delivery, Imaging, and Cancer Sensing. Sci Rep. 2019;9(1):416. https://doi.org/10.1038/s41598018366174Campbell E., Hasan M.T., Pho C., Callaghan K., Akkaraju G. R., Naumov A. V. Graphene Oxide as a Multifunctional Platform for Intracellular Delivery, Imaging, and Cancer Sensing. Sci Rep. 2019;9(1):416. https://doi.org/10.1038/s41598018366174Perini G., Palmieri V., Ciasca G., De Spirito M., Papi M. Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience. Int J Mol Sci. 2020;21(10):3712. https://doi.org/10.3390/ijms21103712Perini G., Palmieri V., Ciasca G., De Spirito M., Papi M. Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience. Int J Mol Sci. 2020;21(10):3712. https://doi.org/10.3390/ijms21103712Ren Y., Miao C., Tang L., Liu Y., Ni P., Gong Y., Li H., Chen F., Feng S. Homotypic Cancer Cell Membranes Camouflaged Nanoparticles for Targeting Drug Delivery and Enhanced ChemoPhotothermal Therapy of Glioma. Pharmaceuticals (Basel). 2022;15(2):157. https://doi.org/10.3390/ph15020157Ren Y., Miao C., Tang L., Liu Y., Ni P., Gong Y., Li H., Chen F., Feng S. Homotypic Cancer Cell Membranes Camouflaged Nanoparticles for Targeting Drug Delivery and Enhanced ChemoPhotothermal Therapy of Glioma. Pharmaceuticals (Basel). 2022;15(2):157. https://doi.org/10.3390/ph15020157Li M., Yang X., Ren J., Qu K., Qu X. Using graphene oxide high near-infrared absorbance for photothermal treatment of Alzheimer’s disease. Adv Mater. 2012;24(13):1722–8. https://doi.org/10.1002/adma.201104864Li M., Yang X., Ren J., Qu K., Qu X. Using graphene oxide high near-infrared absorbance for photothermal treatment of Alzheimer’s disease. Adv Mater. 2012;24(13):1722–8. https://doi.org/10.1002/adma.201104864Park S. Y., Park J., Sim S.H., Sung M. G., Kim K.S., Hong B.H., Hong S. Enhanced differentiation of human neural stem cells into neurons on graphene. Adv Mater. 2011;23(36): H263–7. https://doi.org/10.1002/adma.201101503Park S. Y., Park J., Sim S.H., Sung M. G., Kim K.S., Hong B.H., Hong S. Enhanced differentiation of human neural stem cells into neurons on graphene. Adv Mater. 2011;23(36): H263–7. https://doi.org/10.1002/adma.201101503Li N., Zhang X., Song Q., Su R., Zhang Q., Kong T., Liu L., Jin G., Tang M., Cheng G. The promotion of neurite sprouting and outgrowth of mouse hippocampal cells in culture by graphene substrates. Biomaterials. 2011;32(35):9374–9382, https://doi.org/10.1016/j.biomaterials.2011.08.065Li N., Zhang X., Song Q., Su R., Zhang Q., Kong T., Liu L., Jin G., Tang M., Cheng G. The promotion of neurite sprouting and outgrowth of mouse hippocampal cells in culture by graphene substrates. Biomaterials. 2011;32(35):9374–9382, https://doi.org/10.1016/j.biomaterials.2011.08.065Bei H. P., Yang Y., Zhang Q., Tian Y., Luo X., Yang M., Zhao X. Graphene-Based Nanocomposites for Neural Tissue Engineering. Molecules. 2019;24(4):658. https://doi.org/10.3390/molecules24040658Bei H. P., Yang Y., Zhang Q., Tian Y., Luo X., Yang M., Zhao X. Graphene-Based Nanocomposites for Neural Tissue Engineering. Molecules. 2019;24(4):658. https://doi.org/10.3390/molecules24040658Feng Z. Q., Wang T., Zhao B., Li J., Jin L. Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development. Adv Mater. 2015;27(41):6462–8. https://doi.org/10.1002/adma.201503319Feng Z. Q., Wang T., Zhao B., Li J., Jin L. Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development. Adv Mater. 2015;27(41):6462–8. https://doi.org/10.1002/adma.201503319Jakus A. E., Secor E.B., Rutz A. L., Jordan S. W., Hersam M.C., Shah R.N. Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications. ACS Nano. 2015;9(4):4636–48. https://doi.org/10.1021/acsnano.5b01179Jakus A. E., Secor E.B., Rutz A. L., Jordan S. W., Hersam M.C., Shah R.N. Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications. ACS Nano. 2015;9(4):4636–48. https://doi.org/10.1021/acsnano.5b01179

The authors declare that there are no conflicts of interest present.