polenovjournalРоссийский нейрохирургический журнал имени профессора А. Л. ПоленоваRussian Neurosurgical Journal named after Professor A. L. Polenov2071-2693Семинары, Конференции и Форумыpolenovjournal-460Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSНЕКОТОРЫЕ ОСОБЕННОСТИ РЕЦИДИВИРОВАНИЯ НЕЙРОЭПИТЕЛИАЛЬНЫХ ОПУХОЛЕЙ ГОЛОВНОГО МОЗГА У ДЕТЕЙFEATURES OF RECURRENT NEUROEPITHELIAL BRAIN TUMORS IN CHILDRENhttps://orcid.org/0000-0002-6219-7270КимА. В.KimA. V.

Ким Александр Вонгиевич

Санкт-Петербург

St. Petersburg

https://orcid.org/0000-0002-5114-8713ФедоровЕ. В.FedorovE. V.

Фёдоров Евгений Вадимович

Санкт-Петербург

St. Petersburg

https://orcid.org/0000-0002-1635-6621ШевцовМ. А.ShevtsovM. A.

Хачатрян Вильям Арамович

Санкт-Петербург

St. Petersburg

ХачатрянВ. А.KhachatryanV. A.

Санкт-Петербург

St. Petersburg

Российский научно-исследовательский нейрохирургический институт им. проф. А. Л. Поленова — филиал ФГБУ «Национальный медицинский исследовательский центр им. В. А. Алмазова» Минздрава РоссииРоссияPolenov Scientific Research Neurosurgical Institute — branch of the V. A. Almazov National Medical Research Center, Ministry of Health of RussiaRussian Federation202015032025122916Copyright © Ким А.В., Федоров Е.В., Шевцов М.А., Хачатрян В.А., 20252025Ким А.В., Федоров Е.В., Шевцов М.А., Хачатрян В.А.Kim A.V., Fedorov E.V., Shevtsov M.A., Khachatryan V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://polenovjournal.elpub.ru/jour/article/view/460

В статье представлены результаты исследования факторов риска, особенностей проявления и кинетики повторного роста нейроэпителиальных опухолей (НЭО) головного мозга у детей с целью вероятного прогнозирования рецидива новообразований, а также разработки рациональной тактики их эффективного лечения. Изучены результаты обследования и хирургического лечения 121 пациента детского возраста с рецидивом/продолженным ростом НЭО головного мозга за период с 2008 по 2018 гг. в РНХИ им. проф. А. Л. Поленова и НМИЦ им. В. А. Алмазова. В результате проспективного исследования получены данные о клинико-нейровизуализационных особенностях повторного роста НЭО, выявлены факторы, влияющие на частоту их прогрессии. Впервые в русскоязычной литературе представлены результаты оценки валидности закона Коллинза (Collins’ low) при первичном и повторном рецидивировании НЭО у детей. Показан ряд особенностей роста церебральных нейроэпителиальных новообразований у детей на основе применения метода виртуального 3D-моделирования.

The article presents results of a study of prognostic factors, the features of the manifestation and kinetics of the re- current neuroepithelial brain tumors in children. The authors performed a prospective analysis of data obtained in 121 consecutive patients diagnosed at Polenov Neurosurgical Institute (branch of Almazov National Medical Research Centre) between 2008 and 2018 with a biopsy-proven NET. As a result of a prospective study, data were obtained on the clinical neuroimaging features of the re-growth of NET, factors were identified that affect the frequency of progression of NET in pediatric patients. The results of applying the Collins’ law in the primary and repeated recurrence of NET in children are obtained. The kinetics of growth of cerebral neuroepithelial neoplasms in children was assessed using virtual 3D modeling.  

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Ультраструктурные корреляты механизмов обособленного и комбинированного действия цисплатина, темозоломида, фактора роста нервов в клетках астроцитомы и медуллобластомы человека. Трансляционная медицина. 2019;6(1):27–42. https://doi.org/10.18705/2311-4495-2019-6-1-27-42

The authors declare that there are no conflicts of interest present.