Modification of the experimental model of electrical induced seizures in animals

New medicines for the treatment of epilepsy appear rather rarely, one of the reasons is the lack of reproducible experimental models of different types of seizures. The designs of experimental models for specific seizures are needed.

PURPOSE OF THE STUDY: to modify the experimental model of electrical stimulation of partial and generalized seizures.

MATERIALS AND METHODS: Wistar rats (n=40) were included in this experimental study. The rodents of the first (n=20) group after intracranial electrode implantation and were electrically stimulated for partial seizures; rats of the second group (n=20) were electrically stimulated for generalized seizures. The development of seizures was assessed using the five-point Racine scale.

RESULTS. Modification and adaptation of the experimental model of electrical stimulation of partial and generalized impulse-dependent seizures were made: by controlling the range of impulse amplitude in the experiment, it is possible to induce seizures of various types in rodents.

CONCLUSION. An inexpensive modern, well-reproducible, impulse-dependent model of the formation of simple partial motor seizures and generalized seizures in rats has been modified and tested.

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