Multiple malignant cerebral gliomas. Clinical-pathomorphological features and results of complex treatment
V. E. Trofimov,
A. Yu. Ulitin,
M. V. Matsko,
D. E. Matsko,
S. A. Melchenko,
N. E. Voinov,
O. M. Vorobeva,
G. A. Ulitin https://doi.org/10.56618/20712693_2022_14_4_89
Abstract
Currently, there is no common understanding of the management tactics of multiple malignant cerebral glioma patients. Despite the fact that this pathology accounts for 2 % to 5 % of all glial brain tumors, the domestic literature does not provide clinical recommendations for the complex treatment of this group of patients.
MATERIALS AND METHODS. Clinical cases were selected for the study in 70 patients with multiple cerebral malignant gliomas on the basis of RNSI named after prof. A.L. Polenov. An assessment was made of the radicality of surgical treatment, the effectiveness of adjuvant therapy, and the quality of life after completion of a comprehensive Bartel treatment. The histological examination was performed in all cases for each tumour node separately. The final morphological diagnosis was made after an immunohistochemical study using antibodies: IDH1(R 132H) (H09, Dianova).
CONCLUSION. It was found that the most radical and rapid removal of tumor lesions, given the general brain symptom as leading in the severity of patients, contributes to the most favorable outcome.
About the Authors
V. E. Trofimov
Almazov National Medical Research Centre Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Valeriy E. Trofimov.
Saint-Petersburg, 191014
A. Yu. Ulitin
Almazov National Medical Research Centre Ministry of Health of the Russian Federation; North-West State Medical University, Department of Neurosurgery
Russian Federation
Russian Federation
Alexey Yu. Ulitin.
Saint-Petersburg, 191014; Saint-Petersburg, 195067
M. V. Matsko
Clinical Research and Practical Center for Specialized Oncological Care; Saint-Petersburg State University; Saint-Petersburg Medico-Social Institute
Russian Federation
Russian Federation
Marina V. Matsko.
Saint-Petersburg, 197758; Saint-Petersburg, 199034; Saint-Petersburg, 195271
D. E. Matsko
Russian Federation
S. A. Melchenko
Federal Center of Brain and Neurotechnologies
Russian Federation
Russian Federation
Semen A. Melchenko.
Moscow, 117513
N. E. Voinov
Almazov National Medical Research Centre Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Nikita E. Voinov.
Saint-Petersburg, 191014
O. M. Vorobeva
Almazov National Medical Research Centre Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Saint-Petersburg, 191014
G. A. Ulitin
S.M. Kirov Military Medical Academy
Russian Federation
Russian Federation
Saint-Petersburg, 191015
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For citations:
Trofimov V.E., Ulitin A.Yu., Matsko M.V., Matsko D.E., Melchenko S.A., Voinov N.E., Vorobeva O.M., Ulitin G.A. Multiple malignant cerebral gliomas. Clinical-pathomorphological features and results of complex treatment. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2022;14(4):89-97. (In Russ.) https://doi.org/10.56618/20712693_2022_14_4_89
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