Endovascular superselective embolization of tumor vascular network in the structure of complex treatment of patients with relapsed and continued growth of intracranial meningiomas.
https://doi.org/10.56618/2071-2693_2024_16_2_69
EDN: LTNVNL
Abstract
INTRODUCTION. In this paper, a literature review on the use of intravascular embolization in the treatment of patients with intracranial meningiomas is performed, and an example of using the technique of endovascular superselective chemoembolization of the tumor vascular network in a patient with a recurrent type of intracranial meningioma course is presented.
AIM. To conduct a meta-analysis, to evaluate results of preoperative endovascular superselective embolization of the vascular network of intracranial meningiomas with continued growth and recurrent course, and to present a clinical case.
MATERIALS AND METHODS. We searched Pubmed, EMBASE, Cohrane Library, and eLibrary databases for papers published between January 2010 and January 2023 on embolization of the vascular network of intracranial meningiomas, particularly in recurrence. Endovascular superselective embolization of tumor vascular network was performed in a patient with recurrence of histologically verified meningioma of parasaggital localization. Endovascular treatment was performed with the patient’s voluntary informed consent. Non-adhesive compositions and hypospheres loaded with Doxirubicin were used. In the early postoperative period, clinical, laboratory and intrascopic controls were performed.
RESULTS. The review systematizes the data on the application of techniques of intravascular embolization of meningiomas, presents the latest data on the efficacy of endovascular techniques for the treatment of patients with recurrent meningiomas. The authors conclude that endovascular superselective embolization of tumor vascular network in the structure of complex treatment of patients with relapsed and continued growth of intracranial meningiomas is an effective treatment method. A clinical case of successful application of endovascular techniques in a patient with recurrent meningioma of the base of the middle cranial fossa is presented on the example of our own material.
CONCLUSION. Application of endovascular superselective embolization of tumor vascular network in complex treatment of one of the most complicated groups of patients with recurrent course of neoplastic process (“aggressive” meningiomas) testifies to the effectiveness of this technique for devascularization of meningioma tissues, local administration of cytostatics and local control of tumor growth. Further development of the technology of endovascular super-selective embolization of tumor vascular network in the treatment of patients with “aggressive” meningiomas is necessary.
Keywords
meningioma,
recurrence,
superselective embolization,
non-adhesive composition,
hepasphere microparticles
Supporting agencies: The work was carried out as part of the state assignment No. 123021000128-4 “Development of a new technology for treating patients with secondary brain tumors and recurrent meningiomas”.
About the Authors
K. K. Kukanov
Polenov Neurosurgery Institute – the branch of Almazov National Medical Research Centre
Russian Federation
Russian Federation
Konstantin K. Kukanov – Cand. of Sci. (Med.), Neurosurgeon of the Highest Qualification Category of the Neurosurgical Department No. 4, Senior Researcher at the Institute of Neuro-Oncology
12 Mayakovskogo street, St. Petersburg,191025
K. A. Samochernykh
Polenov Neurosurgery Institute – the branch of Almazov National Medical Research Centre
Russian Federation
Russian Federation
Konstantin A. Samochernykh – Dr. of Sci. (Med.), Professor of the Russian Academy of Sciences, Neurosurgeon of the Highest Category at the Department of Neurosurgery for Children No. 7, Director
12 Mayakovskogo street, St. Petersburg,191025
S. D. Radjabov
Polenov Neurosurgery Institute – the branch of Almazov National Medical Research Centre
Russian Federation
Russian Federation
Said D. Radjabov – Cand. of Sci. (Med.), Associate Professor at the Department of Neurosurgery, Leading Researcher at the Research Institute of Vascular Surgery of the Brain and Spinal Cord, Neurosurgeon of the Highest Qualification Category of the Neurosurgical Department
No. 3
12 Mayakovskogo street, St. Petersburg,191025
K. I. Sebelev
Polenov Neurosurgery Institute – the branch of Almazov National Medical Research Centre
Russian Federation
Russian Federation
Konstantin I. Sebelev – Dr. of Sci. (Med.), Full Professor, Head at the Department of Radiation Diagnostics No. 4, Leading Researcher at the Institute of Pathomorphology of the Nervous System
12 Mayakovskogo street, St. Petersburg,191025
V. E. Olyushin
Polenov Neurosurgery Institute – the branch of Almazov National Medical Research Centre
Russian Federation
Russian Federation
Victor E. Olyushin – Dr. of Sci. (Med.), Full Professor, Honored Doctor of Russia, Neurosurgeon of the Highest Qualification Category, Chief Researcher at the Institute of Neuro-Oncology
12 Mayakovskogo street, St. Petersburg,191025
Author ID: 118325
P. D. Sukhoparov
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Pavel D. Sukhoparov – Student
2 Litovskaya st., street, St. Petersburg, 194100
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For citations:
Kukanov K.K., Samochernykh K.A., Radjabov S.D., Sebelev K.I., Olyushin V.E., Sukhoparov P.D. Endovascular superselective embolization of tumor vascular network in the structure of complex treatment of patients with relapsed and continued growth of intracranial meningiomas. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2024;16(2):69–84. (In Russ.) https://doi.org/10.56618/2071-2693_2024_16_2_69. EDN: LTNVNL
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