Patients` intellectual and memory impairments before and after resection of pituitary adenomas
Abstract
OBJECTIVE. To evaluation patients` intellectual and memory impairments before and after resection of pituitary adenomas
MATERIAL AND METHODS. We performed study of 42 patients with intellectual and memory impairments. The diagnosis of the studied patients was based on clinical and laboratory data, data of radiation and instrumental methods of research. We used the transsphenoidal access for all patients. The analysis of patients` intellectual and memory impairments was carried out in the preoperative and early postoperative periods. The patient` age ranged from 22 to 63 years; the mean age was 43,95±11,3 years; the median age was 45 years.
RESULTS. We found that 40 of the 42 patients studied (95.2%) had various memory impairments in the pre-operative period. Pathological changes in short-term (operative) memory were observed only in the preoperative period in the studied patients. All 42 operated patients recovered short-term (fixation) memory to normal values in the postoperative period. Long- term memory improved in most patients in the postoperative period. The frequency of memory impairments decreased from 38.1% to 9.5% in the postoperative period. It was revealed that the appearance of confubulations increased in the postoperative period in the patients, compared with the preoperative period (71.4% and 64.3%, respectively). We found that after surgery, the number of patients with high intelligence (up to 54.8%), as well as an outstanding level of intelligence (up to 19%) increased.
CONCLUSION. On examination of various memory impairments before and after surgery in patients with pituitary adenomas, it was found that most of the memory impairments in patients regressed. Only paramnesia was more stable, which was preserved in more than half of the patients studied in the early postoperative period. The absence of various intellectual disorders in patients in pre- and postoperative periods was found. There was also an improvement in intelligence after an operative intervention.
About the Authors
V. Yu. Cherebillo
First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
St. Petersburg
M. Yu. Kurnukhina
First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
St. Petersburg
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For citations:
Cherebillo V.Yu., Kurnukhina M.Yu. Patients` intellectual and memory impairments before and after resection of pituitary adenomas. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2019;11(1):60-64. (In Russ.)
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