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Surgical treatment of epilepsy: subjective readiness of patients

Abstract

The intention of the work was to study the subjective indicators of the readiness for neurosurgical treatment of patients with focal pharmacoresistant epilepsy. The study was performed on the basis of Polenov Neurosurgical Institute in 2019–2020.

The study included 53 patients with a verified diagnosis of focal pharmacoresistant epilepsy. Patients were interviewed on a specially designed questionnaire “Subjective readiness for surgical treatment of epilepsy”, including questions: psychology readiness for surgical treatment, the optimal age and age for neurosurgery intervention, according to the patient.

The readiness for surgical treatment of patients with epilepsy in a neurosurgical hospital was 94.3%. Due to the incomplete answers, a quantitative analysis was carried out in 45 patients. The 1st group consisted of 20 patients, the 2nd — 25. The average age in the cohort was 30.96 + 1.07 years. The duration of the disease until surgical treatment or the resolution of the issue of surgical treatment was 19.26 + 1.35 years. The duration of the disease and the optimal age for the operation, according to patients, differed from the age and duration of the disease at the time of stay in the clinic. According to patients, the optimal age of treatment was 18.66 + 1.3 years, and the optimal duration of the disease was 6.94 + 1.02 years, which is 2.8 times less than the actual experience of epilepsy.

The duration of the disease before hospitalization to a neurosurgical hospital is a manageable indicator. Our study demonstrated that patients are psychologically ready for surgical treatment long before the actual terms of the operation. It is necessary to raise the awareness of patients and primary care doctors about the possibilities and principles of the surgical treatment of epilepsy.

About the Authors

V. V. Ushanov
Polenov Neurosurgical Institute — branch of Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University
Russian Federation

St. Petersburg



G. V. Odintsova
Polenov Neurosurgical Institute — branch of Almazov National Medical Research Centre
Russian Federation

St. Petersburg



A. P. Gerasimov
Pavlov First Saint Petersburg State Medical University; Almazov National Medical Research Centre
Russian Federation

St. Petersburg



V. G. Nezdorovina
Polenov Neurosurgical Institute — branch of Almazov National Medical Research Centre
Russian Federation

St. Petersburg



N. E. Ivanova
Polenov Neurosurgical Institute — branch of Almazov National Medical Research Centre
Russian Federation

 St. Petersburg



A. Yu. Ulitin
Polenov Neurosurgical Institute — branch of Almazov National Medical Research Centre
Russian Federation

St. Petersburg



References

1. Epilepsy: a public health imperative. Summary. Geneva: World Health Organization; 2019 (WHO/MSD/MER/19.2). Licence: CC BY-NC-SA 3.0 IGO.

2. Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and life-time epilepsy: a metaanalytic approach. Epilepsia. 2010;51(5):883–890. doi:10.1111/j.1528–1167.2009.02481.x

3. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512–521. doi:10.1111/epi.13709

4. Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies [published correction appears in Epilepsia. 2010 Sep;51(9):1922]. Epilepsia. 2010;51(6):1069–1077. doi:10.1111/j.1528–1167.2009.02397.x

5. Zenkov L. R. Farmakoterapija trudnokurabil’nyh jepilepsij. Jepileptologija v medicine XXI veka. po materialam Konferencii s mezhdunarodnym uchastiem Moskva-Kazan’. Pod redakciej E.I. Guseva, A.B. Gejt. 2009., 2009. S. 521–531. (In Russ.)

6. Krylov, V. V., Guekht, A. B., Trifonov, I. S., Lebedeva, A. V., Kaimovsky, I. L., Sinkin, M. V., Grigorieva, E. V., Grishkina, M. N., Shyshkina, L. V., Kochetkova, O. O. Outcomes of surgical treatment of patients with pharmacoresistant epilepsy. Zhurnal Nevrologii i Psihiatrii Imeni S.S. Korsakova. Special Issue. 2016; 116(9): 13–18. (In Russ.) https://doi.org/10.17116/jnevro20161169213–18.

7. Hirurgija jepilepsii/ Pod redakciej V. V. Krylova — M.: ID «ABVpress», 2019.— 408 s. (In Russ.).

8. Krylov V. V., Gekht A.B., Trifonov I.S., Kaymovskiy I.L., Lebedeva A. V., Prirodov A. V. et al. Klinicheskie rekomendatsii po predoperatsionnomu obsledovaniyu i khirurgicheskomu lecheniyu patsientov s farmakorezistentnymi formami èpilepsii. Moscow; 2015. (In Russ.).

9. Kariev G.M., Jakubov Zh.B., Arslanova Z. Je. Jevoljucija hirurgicheskogo lechenija jepilepsii s pervyh dneĭ do sovremennyh tendenciĭ (obzor literatury) // Zhurnal teoreticheskoĭ i klinicheskoĭ mediciny. 2014; (4): 56–62. (In Russ.).

10. Sitnikov A.R., Skorobogatova V. A., Maslova N. N. Current neurosurgical approaches to treatment of structural epilepsies. Annals of clinical and experimental neurology 2019; 13(1): 70–77. (In Russ.) DOI: 10.25692/ACEN.2019.1.8

11. Schramm J. Epilepsy surgery and the evolution of clinical and translational science. Neurosurgery. 2014;61 Suppl 1:54–65. doi:10.1227/NEU.0000000000000399

12. Odintsova G.V., Aleksandrov M. V., Ulitin A. U., Nezdorovina V. G., Chuchlovin A. A., Koloteva А. V. Unsatisfactory results of a drug resistant epilepsy surgical treatment: reasons analysis and treatment optimization way. Translational Medicine. 2018;5(4):60–68. (In Russ.) https://doi.org/10.18705/2311-4495-2018-5-4-60-68

13. Grinenko O.A., Golovteev A. L., Koptelova A.M., Vorob’ev A.N., Bychenko V. G., Dorofeeva M. Ju., Troickij A. A., Korsakova M.B., Kozlova A.B., Arhipova N. A., Stroganova T. A., Melikjan A. G. Hirurgija jepilepsii pri mnogoochagovom porazhenii golovnogo mozga. Opyt lechenija detej s tuberoznym sklerozom. Vestnik Jepileptologii. 2014; (1–2): 7–20. (In Russ.)

14. Stepanenko A. Ju. Hirurgicheskoe lechenie simptomaticheskoj visochnoj jepilepsii. Nejrohirurgija. 2012; (2): 78–84. (In Russ.)

15. Odintsova G.V., Aleksandrov M. V., Nesterova S. V. The characteristics of social adaptation in reproductive-aged women with epilepsy and migraine. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1S):46–50. (In Russ.) https://doi.org/10.14412/2074–2711–2018–1S46–50

16. Engel J Jr, McDermott MP, Wiebe S, et al. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA. 2012;307(9):922–930. doi:10.1001/jama.2012.220

17. Odintsova G.V., Aleksandrov M. V., Uiitin A. U., Koloteva A. V. CLINICAL FEATURES OF NEUROSURGICAL EPILEPSY PATIENTS. Translational Medicine. 2018;5(2):30–37. (In Russ.) https:// doi.org/10.18705/2311-4495-2018-5-2-30-37

18. Odintsova G.V., Aleksandrov M. V., Ulitin A. Y., Koloteva A. V. Duration of epilepsy and severity of the disease in neurosurgical patients. Epilepsy and paroxysmal conditions. 2018;10(3):44–51. (In Russ.) https://doi.org/10.17749/2077–8333.2018.10.3.044–051

19. Ivanova N. E., Odintsova G. V., Kravtsova S. V., Nezdorovina V. G., Yakovenko I. V., Koloteva A. V., Gerasimov A.P., Sitovskaya D. A., Zabrodskaya Yu. M., Sebelev K.I., Bersnev V. P. Frequency and features of epileptic status in temporal and extratemporal forms of epilepsy. Russian neurosurgical journal named after professor A. L. Polenov. 2019; 11(4): 30–36. (In Russ.)

20. Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus-Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015;56(10):1515–1523. doi:10.1111/epi.13121

21. Mula M, Zaccara G, Galimberti CA, et al. Validated outcome of treatment changes according to International League Against Epilepsy criteria in adults with drug-resistant focal epilepsy. Epilepsia. 2019;60(6):1114–1123. doi:10.1111/epi.14685

22. Shova N.I., Mikhailov V. A., Odintsova G. V., Korovina S. A., Nedorovina V. G., Ivanova N. E., Ulitin A. Yu. Spectrum of psychological disorders in patient with pharmacoresistant epilepsy under conditions of a neurosurgical hospital. Russian neurosurgical journal named after professor A. L. Polenov. 2019; 11(4): 53–58. (In Russ.)

23. Helmstaedter C, Witt JA. Clinical neuropsychology in epilepsy: theoretical and practical issues. Handb Clin Neurol. 2012;107:437–459. doi:10.1016/B978-0-444-52898-8.00036–7


Review

For citations:


Ushanov V.V., Odintsova G.V., Gerasimov A.P., Nezdorovina V.G., Ivanova N.E., Ulitin A.Yu. Surgical treatment of epilepsy: subjective readiness of patients. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2020;12(3):31-36. (In Russ.)

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ISSN 2071-2693 (Print)