A rare case of the spinal cord subependymoma with high level of the proliferative rate index. Case report and a rewiew of literature
A. S. Nechaeva,
V. Ya. Kalmens,
B. Bakhtiyor,
M. M. Tastanbekov,
A. Yu. Ulitin,
D. A. Sitovskaia,
A. A. Chikurov Abstract
A spinal cord subependymomas are uncommon, benign (1–2% of spinal cord tumors), slow-growing tumors with the Ki-67 proliferation index less than 1,5% (WHO grade I). Due to their rarity and lack of characteristic clinicoradiological features, there is limited information currently available regarding their preoperative diagnosis and optimal management strategy. In this case report, we discuss a rare case of multiple spinal cord subependymoma with high level of the proliferative rate. Article provides a literature rewiew on this spinal cord tumor.
About the Authors
A. S. Nechaeva
A.L. Polenov Russian Research Institute of Neurosurgery — branch of V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
V. Ya. Kalmens
A.L. Polenov Russian Research Institute of Neurosurgery — branch of V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
B. Bakhtiyor
A.L. Polenov Russian Research Institute of Neurosurgery — branch of V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
M. M. Tastanbekov
A.L. Polenov Russian Research Institute of Neurosurgery — branch of V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
A. Yu. Ulitin
A.L. Polenov Russian Research Institute of Neurosurgery — branch of V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
D. A. Sitovskaia
A.L. Polenov Russian Research Institute of Neurosurgery — branch of V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
A. A. Chikurov
A.L. Polenov Russian Research Institute of Neurosurgery — branch of V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
References
1. Bansal S. et al. Ten years’ experience in the management of spinal intramedullary tumors in a single institution. Journal of Clinical Neuroscience. 2013 Feb;20(2):292–298. https://doi.org/10.1016/j.jocn.2012.01.056
2. Iwasaki M. et al. Thoracolumbar intramedullary subependymoma with multiple cystic formation: A case report and review. European Spine Journal. 2013 May;22(3):317–320. https://doi.org/10.1007/s00586–012–2357–1
3. Wu L. et al. Surgical outcomes in spinal cord subependymomas: an institutional experience. Journal of neuro-oncology. 2014 Jan;116(1):99–106. https://doi.org/10.1007/s11060–013–1256–6
4. Mikula A. L. et al. Subependymoma involving multiple spinal cord levels: A clinicopathological case series with chromosomal microarray analysis. Neuropathology: official journal of the Japanese Society of Neuropathology. 2019 Apr;39(2):97–105. https://doi.org/10.1111/neup.12543
5. Boström A. et al. Surgery for spinal cord ependymomas: outcome and prognostic factors. Neurosurgery. 2011 Feb;68(2):302–308. https://doi.org/10.1227/neu.0b013e3182004c1e
6. Smith A. B., Smirniotopoulos J. G., Horkanyne-Szakaly I. From the radiologic pathology archives: intraventricular neoplasms: radiologicpathologic correlation. Radiographics: a review publication of the Radiological Society of North America. 2013 Jan;33(1):21–43. https://doi.org/10.1148/rg.331125192
7. Khatri D. et al. Subpial Cervical Subependymoma: Report of an Unusual Tumor with Review of Literature. Asian Journal of Neurosurgery. 2019;14(1):329. https://doi.org/10.4103/ajns.ajns_225_18
8. Wu Z. et al. Intramedullary cervicothoracic subependymoma: report of three cases and review of the literature. Journal of Orthopaedic Science. Springer Tokyo. 2015;20(5):927–934. https://doi.org/10.1007/s00776–014–0585–4
9. Moss T. H. Observation on he nature of subependymoma: an electron microscopic study. Neuropathology and Applied Neurobiology. 1984 Jan;10;63–75. https://doi.org/10.1111/j.1365–2990.1984.tb00341.x
10. Dario A. et al. Subependymoma of the spinal cord: case report and review of the literature. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia. 2001 Jan;8(1):48–50. https://doi.org/10.1054/jocn.2000.0794
11. Boykin F. C. et al. Subependymal glomerate astrocytomas. Journal of neuropathology and experimental neurology. 1954 Jan:13(1):30–49. https://doi.org/10.1097/00005072–195401000–00006
12. Soleiman H. A. et al. Spinal subependymoma surgery: do no harm. Little may be more! Neurosurgical Review. Springer Verlag, 2019 Jun. https://doi.org/10.1007/s10143–019–01128-x
13. Louis D. N. et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathologica. Springer Verlag, 2016 Jun;131(6):803–820. https://doi.org/10.1007/s00401–016–1545–1
14. Krishnan S. S. et al. Cervical Subependymoma: A rare case report with possible histogenesis. Journal of Neurosciences in Rural Practice. 2012 Sep;3(3):366–369. https://doi.org/10.4103/0976–3147.102630
15. Sarkar C. et al. Intramedullary subependymoma of the spinal cord: a case report and review of literature. Clinical neurology and neurosurgery. 2003 Dec;106(1):64–69. https://doi.org/10.1016/j.clineuro.2003.09.003
16. Zrelov A. A., Kukanov K. K., Olyushin V. E. et al. Spinal ependymomas: a literature review and case study. Russian neurosurgical journal named after professor A. L. Polenov. 2015;7(3):66–71 (In Russ.)
17. Do A. S.M.S. et al. Unusual Exophytic Appearance of Spinal Cord Subependymoma. World Neurosurgery. Elsevier Inc., 2019 Jul;127:302–306. https://doi.org/10.1016/j.wneu.2019.03.270
18. Toi H. et al. Bamboo Leaf Sign as a Sensitive Magnetic Resonance Imaging Finding in Spinal Subependymoma: Case Report and Literature Review. Case Reports in Neurological Medicine. 2016 Sep;2016:1–6. https://doi.org/10.1155/2016/9108641
19. Krishnan S. S. et al. Cervical Subependymoma: A rare case report with possible histogenesis. Journal of Neurosciences in Rural Practice. 2012;3(3): 366–369. https://doi.org/10.4103/0976–3147.102630
20. Fu Y. S. et al. Is subependymoma (subependymal glomerate astrocytoma) an astrocytoma or ependymoma? A comparative ultrastructural and tissue culture study. Cancer. 1974 Dec;34(6):1992–2008. https://doi.org/10.1002/1097–0142(197412)34:6%3C1992:: aid-cncr2820340618%3E3.0.co;2-c
21. D’Amico R.S. et al. Subependymomas Are Low-Grade Heterogeneous Glial Neoplasms Defined by Subventricular Zone Lineage Markers. World Neurosurgery. Elsevier Inc. 2017 Nov;107:451–463. https://doi.org/10.1016/j.wneu.2017.08.009
22. Jallo G. I., Zagzag D., Epstein F. Intramedullary subependymoma of the spinal cord. Neurosurgery. 1996 Feb;38(2):251–257. https://doi.org/10.1097/00006123–199602000–00004
23. Nishimura H. et al. A Case of Rapidly-Progressing Cervical Spine Subependymoma with Atypical Features. Spine Surgery and Related Research. Japanese Society for Spine Surgery and Related Research, 2019 Jun;3(1):91–94. https://doi.org/10.22603/ssrr.2018–0005
24. Al-Wahhabi B. et al. Multicentric glioma of the spinal cord. British Journal of Neurosurgery. 2009;6(5):495–499. https://doi.org/10.3109/02688699208995042
25. Wang Z. Y. et al. Comparative analysis on the diagnosis and treatments of multisegment intramedullary spinal cord tumors between the different age groups. Neurosurgical Review. 2012;35(1):85–92. https://doi.org/10.1007/s10143–011–0345–2
26. Ebner F. H. et al. Management of intramedullary spinal cord lesions: Interdependence of the longitudinal extension of the lesion and the functional outcome. European Spine Journal. 2010 Apr;19(4):665– 669. https://doi.org/10.1007/s00586–009–1232–1
27. Sun J. et al. Seldom-segment versus multi-segment intramedullary spinal cord gliomas: a comparative clinical study. Science China Life Sciences. Science in China Press. 2019 Jun:62(6):862–864. https://doi.org/10.1007/s11427–017–9400–7
28. Zhou S. et al. Neuroradiological features of cervical and cervicothoracic intraspinal subependymomas: A study of five cases. Clinical Radiology. 2016 May;71(5);499.e9–499.e15. https://doi.org/10.1016/j.crad.2016.01.017
29. Yuh W. T. et al. Spinal cord subependymoma surgery: A multi-institutional experience. Journal of Korean Neurosurgical Society. 2018 Mar;61(2):233–242. https://doi.org/10.3340/jkns.2017.0405.001
Review
For citations:
Nechaeva A.S., Kalmens V.Ya., Bakhtiyor B., Tastanbekov M.M., Ulitin A.Yu., Sitovskaia D.A., Chikurov A.A. A rare case of the spinal cord subependymoma with high level of the proliferative rate index. Case report and a rewiew of literature. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2019;11(4):64-69. (In Russ.)
Views:
16
Email this article 