Neurocognitive and neuroimaging markers of central nervous system damage in patients with the cerebral variant of postmastectomy syndrome
M. L. Pospelova,
A. E. Nikolaeva,
V. V. Krasnikova,
A. M. Makhanova,
S. N. Tonyan,
O. V. Fionik,
A. Yu. Efimcev,
G. E. Trufanov,
T. M. Alekseeva,
K. A. Samochernykh https://doi.org/10.56618/2071-2693_2025_17_2_72
EDN: LXZHPO
Abstract
INTRODUCTION. Breast cancer is the leading oncological pathology in the female population. Active treatment, including surgery, chemo and radiation therapy, forms a set of disorders. Such complex of disorders is called postmastectomy syndrome. One of the neurological manifestations is the cerebral variant, characterized by impaired memory, attention, a feeling of “unclear” head, in some cases the development of fainting, balance disorders, strokes. Such manifestations reduce the quality of life and require early diagnosis and adequate correction. AIM. Assessment of the brain condition of patients with cerebral manifestations of postmastectomy syndrome using a battery of neurocognitive tests and magnetic resonance morphometry MATERIALS AND METHODS. An open single-center controlled trial was conducted with 86 patients with postmastectomy syndrome and 28 healthy female volunteers. A comprehensive assessment of the patients’ condition was carried out: neurological examination, neurocognitive testing, magnetic resonance morphometry. RESULTS. In women with postmastectomy syndrome, there was a statistically significant decrease in the speed of neurocognitive tests, as well as a decrease in the number of correct answers compared with the group of healthy volunteers. There was also a decrease in the volume of such brain structures as the cerebral cortex, cerebellar cortex, frontal, occipital, parietal lobes, thalamuses, and precentral gyri. CONCLUSION. In patients with the cerebral variant of postmastectomy syndrome, clinical and instrumental signs of damage to the central nervous system are determined. Good survival rates, as well as the high prevalence of neurological manifestations, create the need to create effective and accessible diagnostic strategies, as well as adequate and timely treatment.
Keywords
Supporting agencies: The research was supported by a grant from the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022- 301 dated April 20, 2022).
About the Authors
M. L. Pospelova
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Maria L. Pospelova – Dr. of Sci. (Med.), Associate Professor, Dean at the Faculty of Pre-University Education and Youth Science of the Institute of Medical, Head at the Research Institute of Neuroclinical Oncology
A. E. Nikolaeva
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Nikolaeva Alexandra E. – Postgraduate Student at the Department of Neurology
V. V. Krasnikova
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Krasnikova Varvara V. – Junior Researcher at the Neuroclinical Oncology Research Laboratory
A. M. Makhanova
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Makhanova Albina M. – Junior Researcher at the Neuroclinical Oncology Research Laboratory
S. N. Tonyan
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Samvel N. Tonyan – Postgraduate Student at the Department of Neurology
O. V. Fionik
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Olga V. Fionik – Dr. of Sci. (Med.), Professor at the Department of Cardiovascular Surgery, Head at the Education Cardiovascular Department
A. Yu. Efimcev
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Efimcev Alexander Yu. – Dr. of Sci. (Med.), Associate Professor, Lead Researcher at the Neuroclinical Oncology Research Laboratory
G. E. Trufanov
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Gennadii E. Trufanov – Dr. of Sci. (Med.), Full Professor, Head at the Department of Radiological Diagnostics and Medical Imaging, Chief Researcher of the Radiology Research Department
T. M. Alekseeva
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Tatiana M. Alekseeva – Dr. of Sci. (Med.), Associate Professor, Head at the Department of Neurology and Psychiatry, Leading Researcher at the Research Institute of Cerebrovascular Pathology, Research Institute of Neurology and Neurorehabilitation
K. A. Samochernykh
Polenov Neurosurgery Institute – the branch of Almazov National Medical Research Centre
Russian Federation
Russian Federation
Konstantin A. Samochernykh – Dr. of Sci. (Med.), Professor of the Russian Academy of Sciences, Neurosurgeon of the Highest Category at the Department of Neurosurgery for Children No. 7, Director
References
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For citations:
Pospelova M.L., Nikolaeva A.E., Krasnikova V.V., Makhanova A.M., Tonyan S.N., Fionik O.V., Efimcev A.Yu., Trufanov G.E., Alekseeva T.M., Samochernykh K.A. Neurocognitive and neuroimaging markers of central nervous system damage in patients with the cerebral variant of postmastectomy syndrome. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2025;17(2):72-80. (In Russ.) https://doi.org/10.56618/2071-2693_2025_17_2_72. EDN: LXZHPO
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