Magnetic resonance tractography in ischemic stroke and Alzheimer’s disease
K. M. Shubina,
S. V. Vorobev,
S. N. Yanishevskiy,
A. Yu. Efimtsev,
A. V. Sokolov,
I. K. Ternovyh,
A. M. Tantasheva https://doi.org/10.56618/2071-2693_2025_17_2_127
EDN: IFKJCU
Abstract
Magnetic resonance tractography is a modern method of visualizing the white matter of the brain in vivo. This method allows for a lifetime assessment of the microstructure of the pathways of the central nervous system normally and under the influence of various pathological processes in the form of compression, violation of integrity, breakage. The conductive tracts can change in acute, chronic cerebral circulatory disorders, injuries, demyelinating processes, neurodegenerative diseases, brain tumors and other diseases. Magnetic resonance tractography is widely used in scientific fields of medicine. For several decades, the patterns of changes in the structure of the pathways in certain diseases have been studied. This article provides a review and systematization of data on magnetic resonance tractography in ischemic stroke and Alzheimer’s disease. In particular, the regularities of morphological changes and diffusion characteristics of the white matter of the brain in these diseases are considered. In neurodegenerative pathology, magnetic resonance tractography makes it possible to diagnose chronic progressive brain dis eases in the early stages, which makes it possible to start treatment in a timely manner and reduce the rate of disease progression. In the case of an acute cerebrovascular event, with the help of this diagnostic method, it is possible to determine the degree of damage to the nerve fibers of the white matter, on the basis of which the reversibility of the pathological process is judged, a prognosis for the restoration of lost function is established, an individual rehabilitation treatment program is selected.
Keywords
tractography,
white matter lesion,
ischemic stroke,
Alzheimer’s disease,
diffusion-weighted imaging,
fractional anisotropy
Supporting agencies: The work was carried out within the framework of the State task No. 124021600050-1.
About the Authors
K. M. Shubina
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Kristina M. Shubina – Postgraduate Student at the Department of Neurology with Clinic
S. V. Vorobev
Almazov National Medical Research Centre; Saint-Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Sergej V. Vorobev – Dr. of Sci. (Med.), Associate Professor, Chief Researcher at the Neurology and Neurorehabilitation Research Laboratory, Professor at the Department of Neurology with Clinic Professor at the Clinical Laboratory Diagnostics Department
S. N. Yanishevskiy
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Stanislav N. Yanishevskiy – Dr. of Sci. (Med.), Associate Professor, Head at the Laboratory of Neurology and Neurorehabilitation, Professor at the Department of Neurology with Clinic
A. Yu. Efimtsev
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Aleksandr Yu. Efimtsev – Dr. of Sci. (Med.), Associate Professor, Leading Researcher at the Laboratory of Radiation Imaging
A. V. Sokolov
Almazov National Medical Research Centre; Military Medical Academy named after S. M. Kirov
Russian Federation
Russian Federation
Andrey V. Sokolov – Radiologist at the MRI Department; Head at the MRI Office
I. K. Ternovyh
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Ivan K. Ternovyh – Assistant at the Department of Neurology with Clinic
A. M. Tantasheva
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Anna M. Tantasheva – Neurologist at the Consultative and Diagnostic Center of the University Clinic, Laboratory Research Assistant at the Laboratory of Neurology and Neurorehabilitation
References
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Review
For citations:
Shubina K.M., Vorobev S.V., Yanishevskiy S.N., Efimtsev A.Yu., Sokolov A.V., Ternovyh I.K., Tantasheva A.M. Magnetic resonance tractography in ischemic stroke and Alzheimer’s disease. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2025;17(2):127-138. (In Russ.) https://doi.org/10.56618/2071-2693_2025_17_2_127. EDN: IFKJCU
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