Two-staged stereotactic radiosurgery for the treatment of patients with brain metastases
Abstract
Hypofractionated stereotactic radiosurgery is an effective method of treating brain metastases, if their size or localization do not allow for their single-fraction irradiation. Differences in treatment regimens and patient populations between studies make it difficult to compare and analyze the results.
THE PURPOSE OF THE STUDY: To evaluate the effectiveness of two-stage Gamma knife stereotactic radiosurgery of brain metastases from various cancers.
MATERIALS AND METHODS: retrospective analysis of the results of two-stage stereotactic radiosurgery of 124 intracranial metastases. Irradiation was carried out on Leksell Gamma Knife Perfexion and Icon installations. The median tumor volume was 11.06 cm3. The marginal dose in the first and second stages was in the range of 10–14 GY, the total focal dose varied from 20 to 28 GY. The interval between the stages was 14 days.
RESULTS. The average follow-up period was 9.4 months. Continued growth was registered in 14.3 % of patients, radiation complications in 4.8 %. Local control of BM at 6, 12 and 24 months was 94 %, 86 %, 83 %, respectively.
CONCLUSION. Two-stage hypofractive stereotactic radiosurgery can be considered as the method of choice in the treatment of a complex category of oncological patients with cerebral metastases in the presence of restrictions to perform single irradiation or microsurgical resection.
About the Authors
O. L. Evdokimova
Scientific Research Institute of First Aid to them. N. V. Sklifosovsky
Russian Federation
Russian Federation
Evdokimova Olga Liveryevna
Moscow
V. A. Rak
Scientific Research Institute of First Aid to them. N. V. Sklifosovsky
Russian Federation
Russian Federation
Rak Viacheslav Avgustovich
Moscow
A. S. Tokarev
Scientific Research Institute of First Aid to them. N. V. Sklifosovsky
Russian Federation
Russian Federation
Tokarev Alexey Sergeevich
Moscow
K. V. Koval
Scientific Research Institute of First Aid to them. N. V. Sklifosovsky
Russian Federation
Russian Federation
Koval Konstantin Vladimirovich
Moscow
A. A. Grin
Scientific Research Institute of First Aid to them. N. V. Sklifosovsky
Russian Federation
Russian Federation
Grin Andrey Anatolyevich
Moscow
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Review
For citations:
Evdokimova O.L., Rak V.A., Tokarev A.S., Koval K.V., Grin A.A. Two-staged stereotactic radiosurgery for the treatment of patients with brain metastases. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2022;14(2):73-76. (In Russ.)
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