Photodynamic therapy of supratentorial gliomas
Abstract
The results of treatment of patients with malignant gliomas remain unsatisfactory, despite modern possibilities in the diagnosis and treatment based on molecular genetic data. Photodynamic therapy (PDT) is a method with pathogenetic antitumor mechanisms that differ from radiation therapy and chemotherapy and allows to increase the radicalness of the surgical intervention.
PURPOSE OF THE STUDY. demonstrate the possibilities of photodynamic therapy of malignant glial tumors using chlorin e6.
MATERIALS AND METHODS . A total of 161 patients with a glial tumor of supratentorial localization, a high degree of tumor anaplasia according to Grade (III–IV), who were treated at the N.N. prof. A. L. Polenov. 80 — study group (with photodynamic therapy), 81 — control group (without photodynamic therapy).
RESULTS . The use of photodynamic therapy as part of the complex therapy of gliomas of the brain can increase the median survival of patients with Grade III gliomas up to 40.4±7.4 months (control group — 23.4±3.9 months), for patients with Grade IV gliomas up to 21.3±5.1 months (control group — 13.7±3.7 months) (p=0.0003); and the value of the relapse-free period for patients with Grade III gliomas up to — 22.5±3.79 months (control group — 16.1±3.22 months) (p=0.0002); for patients with Grade IV gliomas up to — 11.4±2.49 months (control group — 8.2±2.13 months) (p=0.0001).
CONCLUSION. PDT can be considered a safe and effective method to increase the radicalness of the operation and improve long-term results of treatment in patients with malignant gliomas.
About the Authors
A. Yu. Rynda
“Russian research Neurosurgical Institute named after prof. A. l. Polenova” — a branch of the Federal State Budgetary Institution “NMITS im. V. A. Almazov” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
St. Petersburg
V. E. Olyushin
“Russian research Neurosurgical Institute named after prof. A. l. Polenova” — a branch of the Federal State Budgetary Institution “NMITS im. V. A. Almazov” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
St. Petersburg
D. M. Rostovtsev
“Russian research Neurosurgical Institute named after prof. A. l. Polenova” — a branch of the Federal State Budgetary Institution “NMITS im. V. A. Almazov” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
St. Petersburg
Yu. M. Zabrodskaya
“Russian research Neurosurgical Institute named after prof. A. l. Polenova” — a branch of the Federal State Budgetary Institution “NMITS im. V. A. Almazov” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
St. Petersburg
G. V. Papayan
“Russian research Neurosurgical Institute named after prof. A. l. Polenova” — a branch of the Federal State Budgetary Institution “NMITS im. V. A. Almazov” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
St. Petersburg
A. Yu. Ulitin
“Russian research Neurosurgical Institute named after prof. A. l. Polenova” — a branch of the Federal State Budgetary Institution “NMITS im. V. A. Almazov” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
St. Petersburg
References
1. Dupont C, Vermandel M, Leroy HA, Quidet M, Lecomte F, Delhem N, Mordon S, Reyns N. Intraoperative photodynamic Therapy for Glioblastomas (INDYGO ): Study Protocol for a Phase I Clinical Trial. Neurosurgery. 2019; 84(6): E 414-E 419. https://doi.org/10.1093/neuros/nyy324
2. Tigliev GS, Olyushin VE , Chesnokova EA, Ulitin AYu, Gelfond ML , Vasilyev DV . Photodynamic therapy in neurooncology: the first experience and a brief review of the literature. Russian Biotherapeutic Journal. 2004; 3(1): 83–89. (In R ussian)
3. Rynda A. Y ., Olyushin V . E ., Rostovtsev D . M . P hotodynamic therapy of cerebral glioma — long term survival, Vestnik Rossiiskoi Voenno-Meditsinskoi Academii, 2017, vol. 2, no. 58, pp. 68–72. (In R ussian)
4. Rynda A. Y u., Rostovtsev D . M ., Olyushin V . E ., Zabrodskaya Yu. M . Therapeutic pathomorphosis in malignant glioma tissues after photodynamic therapy with сhlorin e6 (reports of two clinical cases). Biomedical Photonics. 2020;9(2):45–54. (In R ussian)]. https://doi.org/10.24931/2413‑9432‑2020‑9‑2‑45‑54
5. Kaneko S, Fujimoto S, Yamaguchi H, Yamauchi T, Yoshimoto T, Tokuda K. Photodynamic Therapy of Malignant Gliomas. Progress in Neurological Surgery. 2018; 32: 1–13. https://doi.org/10.1159/000469675.
6. R ynda A Y u. Possibilities of Photodynamic Therapy in the Complex Treatment of Malignant Gliomas. Neurosurgery. 2019; 66(1): 169. https://doi.org/10.1093/neuros/nyz310_811.
7. V ermandel M, Dupont C, Lecomte F, Leroy HA, Tuleasca C, Mordon S, Hadjipanayis CG, Reyns N. Standardized intraoperative 5-ALA photodynamic therapy for newly diagnosed glioblastoma patients: a preliminary analysis of the INDYGO clinical trial. Journal of Neuro-oncology. 2021; 152(3):501–514. https://doi.org/10.1007/s11060‑021‑03718‑6.
8. R ynda A, Olyushin V , Rostovtsev D, Zabrodskaya Yu. L ong-term survival of treatment of HGG using PD T. Neuro-Oncology. 2019; 21(3): iii71. https://doi.org/10.1093/neuonc/noz126.257.
9. Shimizu K, Nitta M, Komori T, Maruyama T, Yasuda T, Fujii Y, Masamune K, Kawamata T, Maehara T, Muragaki Y. Intraoperative Photodynamic Diagnosis Using Talaporfin Sodium Simultaneously Applied for Photodynamic Therapy against Malignant Glioma: A P rospective Clinical Study. Frontiers in Neurology. 2018; 9: 1–9. https://doi.org/10.3389/fneur.2018.00024.
Review
For citations:
Rynda A.Yu., Olyushin V.E., Rostovtsev D.M., Zabrodskaya Yu.M., Papayan G.V., Ulitin A.Yu. Photodynamic therapy of supratentorial gliomas. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2022;14(1-2):99-102. (In Russ.)
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