System analysis of genomic pathology in the cells of the central nervous system: uncovering mechanisms of brain diseases for science-based therapy and neurorehabilitation
Abstract
During the last two decades, it has been demonstrated that genomic pathology manifesting as chromosome and gene mutations as well as genomic and chromosomal instability affects directly the brain. These forms of tissular mosaicism (mosaicism confined to the brain) may cause the wide spectrum of central nervous system (CNS) diseases. To use the results of such studies for developing science-based therapy and neurorehabilitation of severe brain diseases, there is a need for acquiring knowledge about causes and consequences of genomic variations in CNS cells. The most promising methods in this context are system analyses of genomic instability. Uncovering candidate processes for brain diseases and tissue-specific susceptibility to genome instability, these methods give opportunity for molecular therapy and science-based neurorehabilitation.
About the Authors
I. Y. Iourov
Mental Health Research Center; Academician Y. E . Veltishchev Research Clinical Institute of Pediatrics, Pirogov Russian National Medical University; Russian Medical Academy of Continuous Postgraduate Education
Russian Federation
Russian Federation
Moscow
S. G. Vorsanova
Mental Health Research Center; Academician Y. E . Veltishchev Research Clinical Institute of Pediatrics, Pirogov Russian National Medical University
Russian Federation
Russian Federation
Moscow
O. S. Kurinnaia
Mental Health Research Center; Academician Y. E . Veltishchev Research Clinical Institute of Pediatrics, Pirogov Russian National Medical University
Russian Federation
Russian Federation
Moscow
M. A. Zelenova
Mental Health Research Center; Academician Y. E . Veltishchev Research Clinical Institute of Pediatrics, Pirogov Russian National Medical University
Russian Federation
Russian Federation
Moscow
K. S. Vasin
Mental Health Research Center; Academician Y. E . Veltishchev Research Clinical Institute of Pediatrics, Pirogov Russian National Medical University
Russian Federation
Russian Federation
Moscow
Y. B. Yurov
Mental Health Research Center; Academician Y. E . Veltishchev Research Clinical Institute of Pediatrics, Pirogov Russian National Medical University
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Iourov I.Y., Vorsanova S.G., Kurinnaia O.S., Zelenova M.A., Vasin K.S., Yurov Y.B. System analysis of genomic pathology in the cells of the central nervous system: uncovering mechanisms of brain diseases for science-based therapy and neurorehabilitation. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2022;14(1-2):136-138. (In Russ.)
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