Clinical features in recurrence and progression of intracranial meningiomas

INTRODUCTION. Meningiomas account for 18–34 % of all intracranial tumors in adults and are the second most common among all intracranial neoplasms. Recurrence and progression account for 25 %, on average, even after radical tumor resection and radiotherapy., that worsens the prognosis and functional outcome of the disease significantly. Clinical manifestations often occur with large tumor sizes, initial symptoms are not taken into account by patients and by doctors during follow-up after surgery.

PURPOSE. To assess the clinical features in patients with recurrence and progression of intracranial meningiomas and to identify the features of clinical manifestations in the progression of meningiomas.

MATERIALS AND METHODS. The study was based on patients (105 cases) with recurrence and progression of intracranial meningiomas with Grade I – III according to histology, who were treated in the Department of Neurosurgery No. 4 of the Russian Neurosurgical Institute named after professor. A. L. Polenov in the period of time from 2014 to 2022. Assessment of clinical neurological symptoms was performed according to standard methods in clinical practice. The results were evaluated using the software system STATISTICA 10.0.

RESULTS. The multifactorial analysis of the clinical manifestations of the disease in recurrent intracranial meningiomas was performed, the main trends in oncogenesis were identified, and the most common clinical symptoms of tumor progression were identified, which must be taken into account by doctors during follow-up after surgery.

1. Tigliev G. S., Oljushin V. E., Kondrat’ev A. N. Vnutricherepnye meningiomy. SPb.: Rossijskij nejrohirurgicheskij institut im. prof. A. L. Polenova; 2001 (In Russ.).

2. Pospelova M. L., Ternovy`kh I.K., Rudneva V. A., Alekseeva T. M., Olyushin V. E., Efimczev A. Yu., Kukanov K. K., Lepekhina A. S., Ivanova N. E., Ulitin A. Yu. Diagnostika opukholi golovnogo mozga v praktike nevrologa i nejrokhirurga: klinicheskij sluchaj.Rossijskij nejrokhirurgicheskij zhurnal im. professora A. L. Polenova. 2020; 12(3):74–78 (In Russ.) EDN: https://elibrary.ru/YJHINN

3. Kukanov K.K., Vorobyova O. M., Zabrodskaya Yu.M., Potemkina E. G., Ushanov V. V., Tastanbekov M. M., Ivanova N. E. Intracranial meningiomas: clinical, intrascopic and pathomorphological causes of recurrence (literature review). Siberian journal of oncology. 2022;21(4):110–123. (In Russ.) https://doi.org/10.21294/1814‑4861‑2022‑21‑4‑110‑123 EDN: https://elibrary.ru/dbarsi

4. Zabolotny RA , Fedyanin AV, Yulchiev UA , Galkin MV , Kozlov AV . Comprehensive treatment of patients with parasagittal meningiomas. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko. 2019;83(4):121–25. (In Russ., In Engl.) https://doi.org/10.17116/neiro201983041121

5. Kukanov K. K., Ushanov V. V., Zabrodskaya Yu.M., Tastanbekov M. M., Vorobyova O. M., Sitovskaya D. A., Dikonenko M. V. Ways to personalize the treatment of patients with relapse and continued growth of intracranial meningiomas. Russian Journal for Personalized Medicine. 2023;3(3):48–63. (In Russ.) https://doi.org/10.18705/2782‑38062023‑3‑3‑48‑63

6. Certificate of state registration of the database No. RU 2023621571/02.05.2023 Kukanov K. K., Ushanov V. V., Voinov N. E. Register of patients with relapse and continued growth of intracranial meningiomas. EDN: https://elibrary.ru/vbrsbm

7. S. F. Gogorjan, V. P. Bersnev, A. V. Kim. K. A. Samochernykh, Zh. G. M alkhosyan. Opuholi golovnogo mozga, sochetajushhiesja s gidrocefaliej. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko. 2008;4(72):39–42. (In Russ.) EDN: https://elibrary.ru/JXFQID

8. M. Necmettin Pamir, Peter M. Black, Rudolf Fahlbusch. Meningiomas: a comprehensive text. Acta Neurochirurgica. 152. 1445–1445. https://doi.org/10.1007/s00701‑010‑0622‑9

9. Konovalov A N, Kozlov AV, Cherekaev VA, Shimanskiĭ VN, Taniashin SV, Kornienko VN, Pronin IN, Golanov AV, Kobiakov GL, Shishkina LV, Ryzhova MV, Gol’bin DA, Galkin MV, Bocharov AA, Lasunin NV. Meningioma challenge: analysis of 80-year experience of Burdenko Neurosurgical Institute and future. Voprosy Neirokhirurgii Imeni N. N. Burdenko. 2013;77(1):12–23. (In Russ.) EDN: https://elibrary.ru/pyatkb

10. Peyre M, Gauchotte G, Giry M, Froehlich S, Pallud J, Graillon T, Bielle F, Cazals-Hatem D, Varlet P, Figarella-Branger D, Loiseau H, Kalamarides M. De novo and secondary anaplastic meningiomas: a study of clinical and histomolecular prognostic factors. Neuro Oncol. 2018 Jul 5;20(8):1113–1121. https://doi.org/10.1093/neuonc/nox231

11. Shan B, Zhang J, Song Y, Xu J. Prognostic factors for patients with World Health Organization grade III meningiomas treated at a single center. Medicine (Baltimore). 2017 Jun;96(26): e7385. https://doi.org/10.1097/MD.0000000000007385

12. Kondratiev S. A., Kondratieva E. A., Kondratiev A. N., Lesteva N. A., Kukanov K. K., Ivanova N. E. Muscle weakness in the early postoperative period after removal of a brain tumor. Rossiiskii neirokhirurgicheskii zhurnal im. professora A. L. Polenova. 2021; 13(4):51–58. (In Russ.) EDN: ERBXEE

13. Kiiashko S. S., Olushin V. E., Zrelov A. A., Kukanov K. K., Sklyar S. S., Maslova L. N., Ivanova N. E. Staticdynamic disorders in patients after microsurgical resection of the cerebellopontine angle tumors: long-term results. Medical News of North Caucasus. 2022;17(1):10–14. (In Russ.) https://doi.org/10.14300/mnnc.2022.17003

14. Kukanov K. K., Tastanbekov M. M., Olyushin V. E., Pustovoy S. V. Surgical treatment of patients with meningiomas of the foramen magnum: immediate and long-term results. Rossiiskii neirokhirurgicheskii zhurnal im. professora A. L. Polenova. 2017;9(1):36–42. (In Russ.) eLIBRARY ID: 41260938 EDN: https://elibrary.ru/REBCQI

15. Kukanov KK, Tastanbekov MM , Olyushin VE Meningiomas of the foramen magnum: results of surgical and radiosurgical treatment. Rossiiskii neirokhirurgicheskii zhurnal im. professora A. L. Polenova. 2016;8 (4):26–35. (In Russ.) EDN: https://elibrary.ru/LJHXLU eLIBRARY ID: 41235564