Thermophysical modeling and results of an experimental study of laser hyperthermia in gliomas

SUMMARY. Recurrent and initially inoperable small gliomas can be effectively coagulated by minimally invasive laser hyperthermia. The article presents the results of temperature calculations and morphological effects of laser hyperthermia on rat glioma, which are the basis of the method of minimally invasive laser hyperthermia (MILH).

MATERIAL AND METHODS. To predict the spread of heat in gliomas during laser hyperthermia, computer simulation of the process was carried out. Real-time thermometry of glioma hyperthermia was carried out in the experiment. Morphological studies of the area of laser hyperthermia were made on the 7th day after irradiation.

RESULTS. Mathematical modeling predicted the temperature at the fiber tip in diffuse glioma (DG) to reach 194 °C (blue line) and in glioblastoma (GB) to 108 °C (orange line) by the end of irradiation. The estimated size of coagulative necrosis reaches 10.9 mm in HD and 8.7 mm in DG. A study on rat subcutaneous glioma showed that after 30 seconds at 3 mm from the tip of the fiber, the temperature reaches coagulation, at a maximum of 67.4 °C by 60 seconds. Morphologically, the zone of hyperthermia on the 7th day is represented by necrosis, with clear boundaries between the zone of necrosis and the surrounding tissue.

CONCLUSION. Laser hyperthermia with a continuous radiation power not exceeding 2 W, an exposure of 60 seconds, makes it possible to achieve irreversible changes in the tissue. Coagulative necrosis occurs within acceptable temperatures for coagulation.

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