Using QCT to detect drug-induced osteoporosis in patients with epilepsy
Abstract
This paper presents a review of the literature and our own results concerning drug-induced osteoporosis in patients on anticonvulsant therapy. Data on the pathogenesis of bone mineral density disorders depending on the useddrugs and other factors determining the development of osteoporosis are discussed. Quantitative computed tomography data were analyzed in 53 epilepsy patients taking anticonvulsants. Disturbance of bone mineral density (BmD) in the form of osteopenia and osteoporosis was revealed in 23 patients (24 %). A reliable correlation between the number of risk factors and decreased BmD was revealed.
Additional study of pharmacogenetic and laboratory data of osteoporosis risk is required, consideration of which will allow planning of therapy and prescription of drugs regulating BmD in these categories of patients more accurately.
About the Authors
N. I. Ananyeva
V. M. Bekhterev National Medical research Center of psychiatry and neurology
Russian Federation
Russian Federation
St. petersburg
I. A. Trusova
V. M. Bekhterev National Medical research Center of psychiatry and neurology
Russian Federation
Russian Federation
St. petersburg
N. A. Sivakova
V. M. Bekhterev National Medical research Center of psychiatry and neurology
Russian Federation
Russian Federation
St. petersburg
L. V. Lukina
V. M. Bekhterev National Medical research Center of psychiatry and neurology
Russian Federation
Russian Federation
St. petersburg
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Review
For citations:
Ananyeva N.I., Trusova I.A., Sivakova N.A., Lukina L.V. Using QCT to detect drug-induced osteoporosis in patients with epilepsy. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2022;14(2):9-12. (In Russ.)
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