FEATURES OF RECURRENT NEUROEPITHELIAL BRAIN TUMORS IN CHILDREN
Abstract
The article presents results of a study of prognostic factors, the features of the manifestation and kinetics of the re- current neuroepithelial brain tumors in children. The authors performed a prospective analysis of data obtained in 121 consecutive patients diagnosed at Polenov Neurosurgical Institute (branch of Almazov National Medical Research Centre) between 2008 and 2018 with a biopsy-proven NET. As a result of a prospective study, data were obtained on the clinical neuroimaging features of the re-growth of NET, factors were identified that affect the frequency of progression of NET in pediatric patients. The results of applying the Collins’ law in the primary and repeated recurrence of NET in children are obtained. The kinetics of growth of cerebral neuroepithelial neoplasms in children was assessed using virtual 3D modeling.
About the Authors
A. V. Kim
Polenov Scientific Research Neurosurgical Institute — branch of the V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
St. Petersburg
E. V. Fedorov
Polenov Scientific Research Neurosurgical Institute — branch of the V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
St. Petersburg
M. A. Shevtsov
Polenov Scientific Research Neurosurgical Institute — branch of the V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
St. Petersburg
V. A. Khachatryan
Polenov Scientific Research Neurosurgical Institute — branch of the V. A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
St. Petersburg
References
1. Ostrom Q. T., Gittleman H., Xu J., Kromer C., Wolinsky Y., Kruchko C., Barnholtz-Sloan J.S. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009–2013. Neuro Oncol. 2016 Oct 1;18(suppl_5): v1-v75. doi: 10.1093/neuonc/now207.
2. Wisoff J., Boyett J., Berger M., et al. Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children’s Cancer Group Trial No.CCG-945 J Neurosurg 89:52–59, 1998.
3. Sturm D., Filbin M. Gliomas in Children. Semin Neurol 2018;38:121– 130;
4. Ramanan M, Chaseling R: Paediatric brain tumours treated at a single, tertiary paediatric neurosurgical referral centre from 1999 to 2010 in Australia. J Clin Neurosci 19:1387–1391, 2012.
5. Хачатрян В.А., Улитин А. Ю., Кумирова Э. В., Желудкова О. Г., Румянцев А. Г., Ким А. В., Самочерных К. А., Тадевосян А. Р., Дон О. А., Солтан П. С., Пальцев А. А. Медуллобластома (обзор литературы) часть 2. Комплексное лечение. Научно-практический журнал «Нейрохирургия и неврология детского возраста».— 2014.— № 2 (40).— с. 68–80.
6. Ким А.В., Самочерных К. А. Новообразования головного мозга у детей первых двух лет жизни. Ж. Нейрохирургия и неврология детского возраста.— 2010.— № 3–4.— с. 82–94.
7. McGirt MJ, Chaichana KL, Gathinji M, Attenello FJ, Than K, Olivi A, et al: Independent association of extent of resection with survival in patients with malignant brain astrocytoma. Clinical article. J Neurosurg 110:156–162, 2009.
8. Stokland T., Liu J-F., Itonside J. et al. A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702) Neuro-Oncology 12(12):1257–1268, 2010.
9. Kline C., Felton E., Allen E., Tahir P. Mueller S. Survival outcomes in pediatric recurrent high-grade glioma: results of a 20-year systematic review and meta-analysis J Neurooncol. 2018 Mar;137(1):103–110.
10. Song K.S., Phi J. H., Cho B-K. et al. Long-term outcomes in children with glioblastoma J Neurosurg Pediatrics 6:000–000, 2010.
11. Древаль О.Н., Белохвостов А. С., Фениксов В. М. Клинические и цитогенетические факторы прогноза при глиальных опухолях головного мозга. Вопр нейрохир. — 2009.— № 4.— С. 7–13.
12. Tsitlakidis A., Foroglou N., Venetis C et al. Biopsy versus resection in the management of malignant gliomas: a systematic review and metaanalysis. J Neurosurg 2010; 112:5:1020–1032.
13. Youland RS1, Khwaja SS, Schomas DA, Keating GF, Wetjen NM, Laack NN. Prognostic factors and survival patterns in pediatric low-grade gliomas over 4 decades. J Pediatr Hematol Oncol. 2013 Apr;35(3):197–205. doi: 10.1097/MPH.0b013e3182678bf8.
14. Butowski N, Lamborn KR, Berger MS, Prados MD, Chang SM: Historical controls for phase II surgically based trials requiring gross total resection of glioblastoma multiforme. J Neurooncol 85:87–94, 2007.
15. Keles GE, Chang EF, Lamborn KR, Tihan T, Chang CJ, Chang SM, et al: Volumetric extent of resection and residual contrast enhancement on initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytoma. J Neurosurg 105:34–40, 2006.
16. Pope WB, Sayre J, Perlina A, Villablanca JP, Mischel PS, Cloughesy TF: MR imaging correlates of survival in patients with high-grade gliomas. AJNR Am J Neuroradiol 26:2466–2474, 2005.
17. Simpson JR, Horton J, Scott C, Curran WJ, Rubin P, Fischbach J, et al: Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 26:239–244, 1993.
18. Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTKROG). Stangl S, Tontcheva N, Sievert W, Shevtsov M, Niu M, Schmid TE, Pigorsch S, Combs SE, Haller B, Balermpas P, Rödel F, Rödel C, Fokas E, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Stuschke M, Grosu AL, Abdollahi A, Debus J, Belka C, Maihöfer C, Mönnich D, Zips D, Multhoff G. Int J Cancer. 2018 May 1;142(9):1911–1925.
19. Shevtsov M.A., Kim A. V., Samochernych K. A., Romanova I. V., Margulis B.A., Guzhova I. V., Yakovenko I. V., Ischenko A. M., Khachatryan W.A. Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children. Onco Targets Ther. 2014 Jun 18;7:1071–81. doi: 10.2147/ OTT.S62764.
20. Grabowski MM1, Recinos PF, Nowacki AS, Schroeder JL, Angelov L, Barnett GH, Vogelbaum MAResidual tumor volume versus extent of resection: predictors of survival after surgery for glioblastoma. J Neurosurg. 2014 Nov;121(5):1115–23. doi: 10.3171/2014.7.JNS132449. Epub 2014 Sep 5.
21. Dorward IG, Luo J, Perry A, Gutmann DH, Mansur DB, Rubin JB, et al: Postoperative imaging surveillance in pediatric pilocytic astrocytomas. Clinical article. J Neurosurg Pediatr 6:346–352, 2010.
22. Tu A., Robison A., Melamed E., Buchanan I., Hariri O., Babu H., Szymanski L., Krieger M. Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior Pediatr Neurosurg. 2018;53(6):395–400.
23. Kim A., Thompson E., Governale L., Santa C. et al. Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging J Neurosurg Pediatrics 14:356–364, 2014.
24. Tomita T., Volk J., Shen W., Pundy T. Glioneuronal tumors of cerebral hemisphere in children: correlation of surgical resection with seizure outcomes and tumor recurrences. Childs Nerv Syst (2016) 32:1839–1848.
25. Response criteria for phase II studies of supratentorial malignant glioma / D. R. Macdonald, T. L. Cascino, S. C. Schold [et al.] // J. Clin. Oncol. — 1990.— № 8 (7).— Р. 1277–1280.
26. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada /P. Therasse, S. G. Arbuck, E. A. Eisenhauer [et al.] // J Natl Cancer Inst. — 2000. Vol. 92 (3).— P. 205–216.
27. Karpagam, S. Brain Tumor Growth and Volume Detection by Ellipsoid-Diameter Technique Using MRI Data / S. Karpagam, S. Gowri // International Journal of Computer Science Issues. — 2012.— Vol. 9, Issue 2, № 1.— Р. 121–126.
28. Collins VP, Loeffler RK, Tivey H. Observations on growth rates of human tumors. Am J Roentgenol Radium Ther Nucl Med. 1956;76:988–1000.
29. Brown WD, Tavare CJ, Sobel EL, Gilles FH. The applicability of Collins› Law to childhood brain tumors and its usefulness as a predictor of survival. Neurosurg. 1995;36:1093–6.
30. Чернов А. Н. Ультраструктурные корреляты механизмов обособленного и комбинированного действия цисплатина, темозоломида, фактора роста нервов в клетках астроцитомы и медуллобластомы человека. Трансляционная медицина. 2019;6(1):27–42. https://doi.org/10.18705/2311-4495-2019-6-1-27-42
Review
For citations:
Kim A.V., Fedorov E.V., Shevtsov M.A., Khachatryan V.A. FEATURES OF RECURRENT NEUROEPITHELIAL BRAIN TUMORS IN CHILDREN. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2020;12(2):9-16. (In Russ.)
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