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DIAGNOSIS AND SURGICAL TREATMENT OF METASTATIC LESIONS OF THE SPINE: OPPORTUNITIES AND PROSPECTS.

Abstract

Metastatic lesions of the spine are common. Surgical treatment is indicated in most cases with this pathology. The most effective treatment is a combination of surgical and radiation therapy. Currently, there is no single approach to the treatment of metastases in the spine. The article provides a review of the literature on the diagnosis and treatment of metastatic spinal lesions.

About the Authors

S. V. Lyulin
Federal State Budget Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation. Russian Federation
Russian Federation

Yekaterinburg



A. V. Ovsyankin
Federal State Budget Institution “Federal Center of Traumatology, Orthopedics and Endoprosthetics” of the Ministry of Health of the Russian Federation. Russian Federation
Russian Federation

Smolensk



D. S. Ivliev
Federal State Budget Institution “Federal Center of Traumatology, Orthopedics and Endoprosthetics” of the Ministry of Health of the Russian Federation. Russian Federation
Russian Federation

Smolensk



P. I. Balaev
State Budget Institution “Kurgan Regional Oncological Center”
Russian Federation

Kurgan



References

1. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin. 2000;50(1):7–33. doi:10.3322/canjclin.50.1.7

2. Joaquim Andrei F., Ann Powers, Ilya Laufer, Mark H. Bilsky Arq Neuropsiquiatr 2015;73(9):795–802 An update in the anagement of spinal metastases. DOI: 10.1590/0004–282X20150099.

3. Delank KS, Wendtner C, Eich HT, Eysel P: Therapy of spinal metastases. Dtsch Arztebl Int 2011; 108(5): 71–80. DOI: 10.3238/ arztebl.2011.0071.

4. Sciubba DM, Petteys RJ, Dekutoski MB, Fisher CG, et al. Diagnosis and management of metastatic spine disease. A review. J Neurosurg Spine. 2010; 13: 94–108.]

5. White AP, Kwon BK, Lindskog DM, Friedlaender GE. Metastatic disease of the spine. J Am Acad Orthop Surg. 2006; 14: 587–598.

6. Gupta GP, Massagué J. Cancer metastasis: building a framework. Cell. 2006; 127: 679–695.

7. Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain. 1997; 69: 1–18.

8. Laufer I, Sciubba DM, Madera M, Bydon A, Witham TJ, Gokaslan ZL, et al. Surgical management of metastatic spinal tumors. Cancer Control. 2012; 19: 122–128.

9. Sciubba DM, Gokaslan ZL. Diagnosis and management of metastatic spine disease. Surg Oncol. 2006; 15: 141–151.

10. Harel R, Angelov L. Spine metastases: current treatments and future directions. Eur J Cancer. 2010; 46: 2696–2707.

11. Van der Linden YM, Dijkstra SP, Vonk EJ, Marijnen CA, Leer JW. Dutch Bone Metastasis Study Group. Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer. 2005; 103: 320–328.

12. Jacobs WB, Perrin RG. Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus. 2001; 11: e10.

13. Arguello F, Baggs RB, Duerst RE, Johnstone L, McQueen K, Frantz CN. Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer. 1990; 65: 98–106.

14. Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, et al. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine. (2010) 13:324–8. doi: 10.3171/2010.3.SPINE09459

15. Conti Alfredo, Güliz Acker, Anne Kluge, Franziska Loebel, Anita Kreimeier, Volker Budach, Peter Vajkoczy, Ilaria Ghetti, Antonino F. Germano’ and Carolin Senger. Decision Making in Patients With Metastatic Spine. The Role of Minimally Invasive Treatment Modalities. Front. Oncol., 19 September 2019 https://doi.org/10.3389/ fonc.2019.00915

16. Oshima K, Hashimoto N, Sotobori T, Joyama S, Tanigami H, Nakanishi K, et al. New magnetic resonance imaging features predictive for post-treatment ambulatory function: imaging analysis of metastatic spinal cord compression. Spine. (2016) 41: E422–9. doi: 10.1097/BRS.0000000000001308

17. Edelstyn GA, Gillespie PJ, Grebbell FS. The radiological demonstration of osseous metastases. Experimental observations. Clin Radiol. 1967; 18: 158–162.

18. Jung HS, Jee WH, McCauley TR, Ha KY, Choi KH. Discrimination of metastatic from acute osteoporotic compression spinal fractures with MR imaging. Radiographics. 2003; 23: 179–187.

19. Buhmann Kirchhoff S, Becker C, Duerr HR, Reiser M, Baur-Melnyk A. Detection of osseous metastases of the spine: comparison of high resolution multi-detector-CT with MRI. Eur J Radiol. 2009; 69: 567–573.]

20. Eleraky M, Papanastassiou I, Vrionis FD. Management of metastatic spine disease. Curr Opin Support Palliat Care. 2010; 4: 182–188

21. Bhatt AD, Schuler JC, Boakye M, Woo SY. Current and emerging concepts in non-invasive and minimally invasive management of spine metastasis. Cancer Treat Rev. 2013; 39: 142–152.].

22. Bai J, Bakula A, Fellows DW, Ollenschleger MD, Kureshi IU, Spiegel GR. Novel application of 3-dimensional rotational C-arm conebeam CT angiography for metastatic hypervascular tumor mass in the spine. Spine (Phila Pa 1976). 2013; 39: e300–303

23. Costelloe CM, Rohren EM, Madewell JE, Hamaoka T, Theriault RL, Yu TK, et al. Imaging bone metastases in breast cancer: techniques and recommendations for diagnosis. Lancet Oncol. 2009; 10: 606–614.

24. Scutellari PN, Antinolfi G, Galeotti R, Giganti M. [Metastatic bone disease. Strategies for imaging]. Minerva Med. 2003; 94: 77–90.

25. Savelli G, Maffioli L, Maccauro M, De Deckere E, Bombardieri E. Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions. Q J Nucl Med. 2001; 45: 27–37.

26. Even-Sapir E, Martin RH, Barnes DC, Pringle CR, Iles SE, Mitchell MJ. Role of SPECT in differentiating malignant from benign lesions in the lower thoracic and lumbar vertebrae. Radiology. 1993; 187: 193–198

27. Gates GF. SPECT imaging of the lumbosacral spine and pelvis. Clin Nucl Med. 1988; 13: 907–914.

28. Helyar V, Mohan HK, Barwick T, Livieratos L, Gnanasegaran G, Clarke SE, et al. The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate. Eur J Nucl Med Mol Imaging. 2010; 37: 706–713.

29. Zhang Y, Shi H, Gu Y, Xiu Y, Li B, Zhu W, et al. Differential diagnostic value of single-photon emission computed tomography/ spiral computed tomography with tc-99m-methylene diphosphonate in patients with spinal lesions. Nucl Med Commun. 2011; 32: 1194–1200

30. Costelloe CM, Rohren EM, Madewell JE, Hamaoka T, Theriault RL, Yu TK, et al. Imaging bone metastases in breast cancer: techniques and recommendations for diagnosis. Lancet Oncol. 2009; 10: 606–614.

31. Poulsen MH, Petersen H, Høilund-Carlsen PF, Jakobsen JS, Gerke O, Karstoft J, et al. Spine Metastases in Prostate Cancer: Comparison of [99m Tc] MDP Wholebody Bone Scintigraphy, [18 F] Choline PET/CT, and [18 F]NaF PET/CT. BJU Int. 2013

32. Schirrmeister H, Guhlmann A, Elsner K, Kotzerke J, Glatting G, Rentschler M, et al. Sensitivity in detecting osseous lesions depends on anatomic localization: planar bone scintigraphy versus 18F PET. J Nucl Med. 1999; 40: 1623–1629.

33. Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I. Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol. 1998; 16: 3375–3379

34. Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: A randomised trial. The Lancet. 2005; 366: 643–648

35. Witham TF, Khavkin YA, Gallia GL, Wolinsky JP, Gokaslan ZL. Surgery insight: current management of epidural spinal cord compression from metastatic spine disease. Nat Clin Pract Neurol. 2006; 2: 87–94.

36. Bartels RH, van der Linden YM, van der Graaf WT. Spinal extradural metastasis: review of current treatment options. CA Cancer J Clin. 2008; 58: 245–259.

37. Popovic M, Lemke M, Zeng L, Chen E, et al. Comparing prognostic factors in patients with spinal metastases: a literature review. Expert Rev Pharmacoecon Outcomes Res. 2012; 12: 345–356

38. Bauer HC, Wedin R. Survival after surgery for spinal and extremity metastases. Prognostication in 241 patients. Acta Orthop Scand. 1995; 66: 143–146.

39. Sioutos PJ, Arbit E, Meshulam CF, Galicich JH. Spinal metastases from solid tumors. Analysis of factors affecting survival. Cancer. 1995; 76: 1453–1459.

40. Tokuhashi Y, Matsuzaki H, Oda H, Oshima M. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 2005; 30: 2186–2191..

41. Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine (Phila Pa 1976). 2001; 26: 298–306

42. Tokuhashi Y, Matsuzaki H, Toriyama S, Kawano H, Ohsaka S. Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 1990; 15: 1110–1113

43. Wibmer C, Leithner A, Hofmann G, Clar H, Kapitan M, Berghold A, et al. Survival analysis of 254 patients after manifestation of spinal metastases: Evaluation of seven preoperative scoring systems. Spine (Phila Pa 1976). 2011; 36: 1977–1986.

44. Leithner A, Radl R, Gruber G, Hochegger M, Leithner K, Welkerling H, et al. Predictive value of seven preoperative prognostic scoring systems for spinal metastases. Eur Spine J. 2008; 17: 1488–1495

45. Chen H, Xiao J, Yang X, Zhang F, Yuan W. Preoperative scoring systems and prognostic factors for patients with spinal metastases from hepatocellular carcinoma. Spine (Phila Pa 1976). 2010; 35: E1339–1346

46. Kaloostian PE, Yurter A, Zadnik PL, Sciubba DM, Gokaslan ZL. Current paradigms for metastatic spinal disease: an evidence-based review. Ann Surg Oncol. 2014; 21: 248–262.

47. Majeed H, Kumar S, Bommireddy R, Klezl Z, Calthorpe D. Accuracy of prognostic scores in decision making and predicting outcomes in metastatic spine disease. Ann R Coll Surg Engl. 2012; 94: 28–33.

48. Gregory TM, Coriat R, Mir O. Prognostic scoring systems for spinal metastases in the era of anti-VEGF therapies. Spine (Phila Pa 1976). 2013; 38: 965–966

49. Beuselinck B, Oudard S, Rixe O, Wolter P, Blesius A, Ayllon J, et al. Negative impact of bone metastasis on outcome in clear-cell renal cell carcinoma treated with sunitinib. Ann Oncol. 2011; 22: 794–800.

50. Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, et al. A novel classification system for spinal instability in neoplastic disease: An evidence-based approach and expert consensus from the spine oncology study group. Spine. 2010; 35: E1221-E1229.

51. Fourney DR, Frangou EM, Ryken TC, Dipaola CP, Shaffrey CI, Berven SH, et al. Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group. J Clin Oncol. 2011; 29: 3072–3077

52. Sciubba DM, Gokaslan ZL, Suk I, Suki D, Maldaun MV, McCutcheon IE, et al. Positive and negative prognostic variables for patients undergoing spine surgery for metastatic breast disease. Eur Spine J. 2007; 16: 1659–1667

53. Yurter A, Ju DG, Sciubba DM (2014) Management of Metastatic Spine Disease. JSM Neurosurg Spine 2(2): 1020.

54. Sayama CM, Schmidt MH, Bisson EF. Cervical spine metastases: techniques for anterior reconstruction and stabilization. Neurosurg Rev. 2012; 35: 463–474

55. Liu JK, Apfelbaum RI, Schmidt MH. Surgical management of cervical spinal metastasis: anterior reconstruction and stabilization techniques. Neurosurg Clin N Am. 2004; 15: 413–424

56. Fehlings MG, David KS, Vialle L, Vialle E, Setzer M, Vrionis FD. Decision making in the surgical treatment of cervical spine metastases. Spine (Phila Pa 1976). 2009; 34: S108–117

57. Polly DW Jr, Chou D, Sembrano JN, Ledonio CG, Tomita K. An analysis of decision making and treatment in thoracolumbar metastases. Spine (Phila Pa 1976). 2009; 34: S118–127

58. Quraishi NA, Gokaslan ZL, Boriani S. The surgical management of metastatic epidural compression of the spinal cord. J Bone Joint Surg Br. 2010; 92: 1054–1060

59. Huang TJ, Hsu RW, Liu HP, Shih HN, Liao YS, Hsu KY, et al. Video-assisted thoracoscopic surgery to the upper thoracic spine. Surg Endosc. 1999; 13: 123–126

60. Fang T, Dong J, Zhou X, McGuire RA Jr, Li X. Comparison of miniopen anterior corpectomy and posterior total en bloc spondylectomy for solitary metastases of the thoracolumbar spine. J Neurosurg Spine. 2012; 17: 271–279

61. Huang TJ, Hsu RW, Li YY, Cheng CC. Minimal access spinal surgery (MASS) in treating thoracic spine metastasis. Spine (Phila Pa 1976). 2006; 31: 1860–1863

62. Rose PS, Clarke MJ, Dekutoski MB. Minimally invasive treatment of spinal metastases: techniques. Int J Surg Oncol. 2011; 2011: 494381

63. Laufer I, Madera M, Bydon A, Witham TJ, Wolinsky J, Gokaslan ZL, et al. Minimally invasive surgery in the treatment of thoracolumbar metastatic tumors. ArgoSpine News & Journal. 2011; 23: 134–138.

64. Smith ZA, Fessler RG. Paradigm changes in spine surgery: evolution of minimally invasive techniques. Nat Rev Neurol. 2012; 8: 443–450.

65. Smith ZA, Yang I, Gorgulho A, Raphael D, De Salles AA, Khoo LT. Emerging techniques in the minimally invasive treatment and management of thoracic spine tumors. J Neurooncol. 2012; 107: 443–455

66. Taghva A, Li KW, Liu JC, Gokaslan ZL, Hsieh PC. Minimally invasive circumferential spinal decompression and stabilization for symptomatic metastatic spine tumor: technical case report. Neurosurgery. 2010; 66: E620–622.

67. Kimball J, Kusnezov NA, Pezeshkian P, Lu DC. Minimally invasive surgical decompression for lumbar spinal metastases. Surg Neurol Int. 2013; 4: 78.

68. Deutsch H, Boco T, Lobel J. Minimally invasive transpedicular vertebrectomy for metastatic disease to the thoracic spine. J Spinal Disord Tech. 2008; 21: 101–105

69. Allen RT, Garfin SR. The economics of minimally invasive spine surgery: the value perspective. Spine (Phila Pa 1976). 2010; 35: S375–382

70. Zairi F, Arikat A, Allaoui M, Marinho P, Assaker R. Minimally invasive decompression and stabilization for the management of thoracolumbar spine metastasis. J Neurosurg Spine. 2012; 17: 19–23.

71. Fang T, Dong J, Zhou X, McGuire RA Jr, Li X. Comparison of miniopen anterior corpectomy and posterior total en bloc spondylectomy for solitary metastases of the thoracolumbar spine. J Neurosurg Spine. 2012; 17: 271–279.

72. Taghva A, Li KW, Liu JC, Gokaslan ZL, Hsieh PC. Minimally invasive circumferential spinal decompression and stabilization for symptomatic metastatic spine tumor: technical case report. Neurosurgery. 2010; 66: E620–622.

73. Lu DC, Chou D, Mummaneni PV. A comparison of mini-open and open approaches for resection of thoracolumbar intradural spinal tumors. J Neurosurg Spine. 2011; 14: 758–764.

74. Jandial R, Chen MY. Mini-open transpedicular lumbar vertebrectomy reconstructed with double cages and short segment fixation. Surg Neurol Int. 2012; 3: S362–365.

75. Massicotte E, Foote M, Reddy R, Sahgal A. Minimal access spine surgery (MASS) for decompression and stabilization performed as an out-patient procedure for metastatic spinal tumours followed by spine stereotactic body radiotherapy (SBRT): First report of technique and preliminary outcomes. Technol Cancer Res Treat. 2012; 11: 15–25.

76. Nzokou A, Weil AG, Shedid D. Minimally invasive removal of thoracic and lumbar spinal tumors using a nonexpandable tubular retractor. J Neurosurg Spine. 2013; 19: 708–715.

77. Molina CA, Gokaslan ZL, Sciubba DM. A systematic review of the current role of minimally invasive spine surgery in the management of metastatic spine disease. Int J Surg Oncol. 2011; 2011: 598148.

78. Shi HB, Suh DC, Lee HK, Lim SM, Kim DH, Choi CG, et al. Preoperative transarterial embolization of spinal tumor: embolization techniques and results. AJNR Am J Neuroradiol. 1999; 20: 2009–2015

79. Harel R, Angelov L. Spine metastases: current treatments and future directions. Eur J Cancer. 2010; 46: 2696–2707

80. Thiex R, Harris MB, Sides C, Bono CM, Frerichs KU. The role of preoperative transarterial embolization in spinal tumors. A large single-center experience. Spine J. 2013; 13: 141–149

81. Laufer I, Rubin DG, Lis E, Cox BW et al. The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist. 2013; 18: 744–751

82. Laufer I, Iorgulescu JB, Chapman T, Lis E, et al. Local disease control for spinal metastases following “separation surgery” and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients. J Neurosurg Spine. 2013; 18: 207–214.

83. Wang JC, Boland P, Mitra N, Yamada Y, et al. Single-stage posterolateral transpedicular approach for resection of epidural metastatic spine tumors involving the vertebral body with circumferential reconstruction: Results in 140 patients: Invited submission from the joint section meeting on disorders of the spine and peripheral nerves, march 2004. Journal of Neurosurgery: Spine. 2004; 1: 287–298

84. Moulding HD, Elder JB, Lis E, Lovelock DM, et al. Local disease control after decompressive surgery and adjuvant high-dose singlefraction radiosurgery for spine metastases. J Neurosurg Spine. 2010; 13: 87–93.

85. Chen KY, Ma HI, Chiang YH. Percutaneous transpedicular vertebroplasty with polymethyl methacrylate for pathological fracture of the spine. J Clin Neurosci. 2009; 16: 1300–1304.

86. Pilitsis JG, Rengachary SS. The role of vertebroplasty in metastatic spinal disease. Neurosurg Focus. 2001; 11: e9.

87. Denaro V, Longo UG, Maffulli N, Denaro L. Vertebroplasty and kyphoplasty. Clin Cases Miner Bone Metab. 2009; 6: 125–130.

88. Kassamali RH, Ganeshan A, Hoey ET, Crowe PM, Pain management in spinal metastases: the role of percutaneous vertebral augmentation. Ann Oncol. 2011; 22: 782–786

89. Hulme PA, Krebs J, Ferguson SJ, Berlemann U. Vertebroplasty and kyphoplasty: a systematic review of 69 clinical studies. Spine (Phila Pa 1976). 2006; 31: 1983–2001

90. Anselmetti GC, Manca A, Kanika K, Murphy K, et al. Temperature measurement during polymerization of bone cement in percutaneous vertebroplasty: an in vivo study in humans. Cardiovasc Intervent Radiol. 2009; 32: 491–498.

91. Yimin Y, Zhiwei R, Wei M, Jha R. Current status of percutaneous vertebroplasty and percutaneous kyphoplasty — a review. Med Sci Monit. 2013; 19: 826–836. C. Rory Goodwin Mohamed H. Khattab Eric W. Sankey et al. Factors Associated with Life Expectancy in Patients with Metastatic Spine Disease from Adenocarcinoma of the Lung. Global Spine J 2015;5:417–424. DOI http://dx.doi.org/10.1055/s-0035–1554778.

92. Santini D, Daniele S, Barni S, et al. Natural history of non-small-cell lung cancer with bone metastases. Sci Rep 2015;5:18670.doi:10.1038/ srep18670].

93. Matheus Fernandes de Oliveira, Jose Marcus Rotta, Ricardo Vieira Botelho Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status. Arq Neuropsiquiatr 2015;73(4):330–335 DOI: 10.1590/0004– 282X20150003

94. Chenglong Zhao, Zhichao Zhang, Nanzhe Zhong, Tianqi Fan. Outcomes and prognostic factors for surgically treated patients with breast cancer spine metastases. Journal of Bone Oncology 12 (2018) 38-43 https://doi.org/10.1016/j.jbo.2018.03.003.

95. Wibmer C, Leithner A, Hofmann G, Clar H et al. Survival analysis of 254 patients after manifestation of spinal metastases: evaluation of seven preoperative scoring systems. Spine. 2011;36(23):1977–86. http://dx.doi.org/10.1097/BRS.0b013e3182011f84,

96. Le R, Tran J D, Lizaso M, et al. (October 03, 2018) Surgical Intervention vs. Radiation Therapy: The Shifting Paradigm in Treating Metastatic Spinal Disease. Cureus 10(10): e3406. DOI 10.7759/cureus.3406.

97. George R, Jeba J, Ramkumar G, et al.: Interventions for the treatment of metastatic extradural spinal cord compression in adults. Cochrane Database Syst Rev. 2015, 9: CD006716. 10.1002/14651858. CD006716.pub3.

98. Payne WG, Walusimbi MS, Blue ML, Mosiello G. Radiated groin wounds: pitfalls in reconstruction. Am Surg. (2003) 69:994–7.

99. Itshayek E, Yamada J, Bilsky M, Schmidt M, et al. Timing of surgery and radiotherapy in the management of metastatic spine disease: a systematic review. Int J Oncol. (2010) 36:533–44. doi: 10.3892/ ijo_00000527.

100. Ghogawala Z, Mansfield FL, Borges LF. Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression. Spine. (2001) 26:818–24. doi: 10.1097/00007632-200104010-00025

101. Wang J, Boerma M, Fu Q, Hauer-Jensen M. Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome. Hernia. (2006) 10:502–6. doi: 10.1007/s10029–006–0150-y 103.Payne WG, Naidu DK, Wheeler CK, Barkoe D, Mentis M, Salas

102. RE, et al. Wound healing in patients with cancer. Eplasty. (2008). 104.Gerszten PC, Germanwala A, Burton SA, Welch WC, Ozhasoglu C,

103. Vogel WJ. Combination kyphoplasty and spinal radiosurgery: A new treatment paradigm for pathological fractures. J Neurosurg Spine. 2005; 3: 296–301.

104. Gerszten PC, Monaco EA 3rd. Complete percutaneous treatment of vertebral body tumors causing spinal canal compromise using a transpedicular cavitation, cement augmentation, and radiosurgical technique. Neurosurg Focus. 2009; 27: E9

105. Georgy BA, Wong W. Plasma-mediated radiofrequency ablation assisted percutaneous cement injection for treating advanced malignant vertebral compression fractures. AJNR Am J Neuroradiol. 2007; 28: 700–705.

106. Dupuy DE, Liu D, Hartfeil D, Hanna L, Blume JD, Ahrar K, et al. Percutaneous radiofrequency ablation of painful osseous metastases: a multicenter American College of Radiology Imaging Network trial. Cancer. 2010; 116: 989–997.

107. Kurup AN, Callstrom MR. Ablation of skeletal metastases: current status. J Vasc Interv Radiol. 2010; 21: S242–250.

108. Kollender Y, Meller I, Bickels J, Flusser G, Issakov J, Merimsky O, et al. Role of adjuvant cryosurgery in intralesional treatment of sacral tumors. Cancer. 2003; 97: 2830–2838

109. Zadnik PL, Hwang L, Ju DG, Groves ML, et al. Prolonged survival following aggressive treatment for metastatic breast cancer in the spine. Clin Exp Metastasis. 2014; 31: 47–55.


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For citations:


Lyulin S.V., Ovsyankin A.V., Ivliev D.S., Balaev P.I. DIAGNOSIS AND SURGICAL TREATMENT OF METASTATIC LESIONS OF THE SPINE: OPPORTUNITIES AND PROSPECTS. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2020;12(2):69-78. (In Russ.)

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