Results of the sex hormones study in female vegetative state(unresponsive wakefulness syndro me) patients
Abstract
It is known that vegetative state (VS)/unresponsive wakefulness syndrome (UWS) patients usually have oligo- or amenorrhea. In some cases, there is a resumption of the menstrual reaction a few months before consciousness restoration. This study contributes understanding of the mechanisms of formation of a stable pathological state of the brain, and may also help to develop approaches to the treatment of this category of patients. Research of sex hormones in 33 female with different etiology and duration of VS/UWS was conducted.
The aim of the study was investigation of the gonadotropic and ovarian in VS/UWS female patients. As a result of the conducted research, two forms of ovarian insufficiency were revealed: hypogonadotropic in 42.86 % and normogonadotropic in 57.14 %.
About the Authors
Е. А. KondratievaRussian Federation
St. Petersburg
А. О. Ivanova
Russian Federation
St. Petersburg
N. V. Driagina
Russian Federation
St. Petersburg
S. A. Kondratiev
Russian Federation
St. Petersburg
M. I. Yarmolinskaya
Russian Federation
St. Petersburg
N. E. Ivanova
Russian Federation
St. Petersburg
A. N. Kondratiev
Russian Federation
St. Petersburg
References
1. Пирадов, М. А. Хронические нарушения сознания: терминология и диагностические критерии. Результаты первого заседания Российской рабочей группы по проблемам хронических нарушений сознания / М. А. Пирадов, Н. А. Супонева, И. А. Вознюк, А. Н. Кондратьев и др. // Анналы клинической и экспериментальной неврологии. — 2020. — 14(1). — С. 5–16.
2. Пирадов, М. А. Возможности современных методов нейровизуализации в изучении спонтанной активности головного мозга в состоянии покоя / М. А. Пирадов, Н. А. Супонева, Ю. А. Селиверстов [и др.] // Неврол. журн. — 2016. — № 21(1). — C. 4–12.
3. Пирадов М. А. Структурно–функциональные основы хронических нарушений сознания / М. А. Пирадов, Н. А. Супонева, Д. В. Сергеев [и др.] Анналы клин. и эксперим. неврологии. — 2018. —Т. 12, № 5. — С. 6–15.
4. Giacino, J. T. P ractice guideline update recommendations summary: disorders of consciousness: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research / J. T. Giacino, D. I. Katz, N. D . Schiff et al. // Neurology. — 2018. — Vol. 91, № 10. — P. 450–460.
5. Kondziella, D. E uropean Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness [Electronic resource] / D. Kondziella, A. Bender, K. D iserens et al. // Eur. J. Neurol. — 2020. — Vol. 23. — Access mode: http: // doi. 10.1111/ene.14151.
6. M unno I. E valuation of hypothalamic–pituitary–adrenocortical hormones and inflammatory cytokines in patients with persistent vegetative state / I. M unno, S. D amiani, R. Scardapane et al. // Immunopharmacol. Immunotoxicol. ‒ 1998. ‒ Vol. 20, № 4. ‒ Р. 519‒522.
7. R oyal College of Physicians. Prolonged disorders of consciousness following sudden onset brain injury: National clinical guidelines. — London, 2020. — 200p.
8. Schnakers, C. Steven Laureys (eds.) Coma and Disorders of consciousness, second edition, Springer 2018
9. Van Erp, W. S. The vegetative state: prevalence, misdiagnosis, and treatment limitations / W. S. van Erp, J.C. M. L avrijsen, P. E . Vos et al. // J. A m. M ed. Dir. Assoc. — 2015. — Vol. 16, № 1. — 85.e 9–85. e14.
10. Y oshimoto, H. A nterior pituitary function in the vegetative state / H. Y oshimoto, T. U ozumi // Neurol. Med. Chir (Tokyo). ‒ 1989. ‒ Vol. 29, № 6. ‒ Р. 490‒495.
Review
For citations:
Kondratieva Е.А., Ivanova А.О., Driagina N.V., Kondratiev S.A., Yarmolinskaya M.I., Ivanova N.E., Kondratiev A.N. Results of the sex hormones study in female vegetative state(unresponsive wakefulness syndro me) patients. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2020;12(4):27-31. (In Russ.)