Factors affecting the transformation of anaplastic glioma to glioblastoma
Abstract
Anaplastic glioma although more favorable than glioblastoma even after complex treatment, mostly progress and transform into glioblastoma when they reoccur. The aim of this research was to study the clinical, survival rate and factors influencing the transformation of anaplastic glioma to glioblastoma.
We retrospectively studied from 2002 to 2020, patients with anaplastic glioma, whose tumors transformed into glioblastoma. We studied the clinical and the overall survival. A total of 101 patients with anaplastic glioma of which 29 transformed into glioblastoma were studied with an average age of 48 years and comprising of 17 men 12 women. The mean time to transformation of glioblastoma was 31 months. Overall survival was 44.50 months. The survival rate after transformation was 13.5 months. The transformation of anaplastic glioma into glioblastoma affects the treatment protocol of patients, since transformation is most often detected after the histology of re-resection has been confirmed. Treatment of anaplastic glioma should be individualized, taking into account molecular markers, age, and degree of resection. Further research should also focus more on the prevention or early treatment of transformed gliomas.
About the Authors
S. K. BaduRussian Federation
Nizhny Novgorod
I. A. Medynik
Russian Federation
Nizhny Novgorod
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Review
For citations:
Badu S.K., Medynik I.A. Factors affecting the transformation of anaplastic glioma to glioblastoma. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2021;13(2):14-17. (In Russ.)