On the prediction of postoperative recurrence of meningioma
I. V. Balyazin-Parfenov,
V. A. Balyazin,
S. S. Todorov,
V. Y. Deribas,
V. E. Khatyushin,
N. R. Saburov Abstract
Numerous studies of the pathogenesis of meningiomas, frequent changes in the tumor suppressor genes CDKN 2A, p14ARF and CDKN 2B in the 9p21 region, as well as gene amplification in the 17q23 region. The value of prognostic markers of proliferation, especially MIB‑ 1, was noted. Ki‑67 antibodies do not fully solve the problem of predicting tumor recurrences. A comparative analysis of the results of an immunohistochemical study of the nuclear expression of the Ki‑67 proliferation index with diffuse nuclear expression of the Cyclin-D 1 protein in patients with recurrent meningotheliomatous meningiomas was performed. It turned out that in the structures of meninotheliomatous meningioma, there is a pronounced nuclear expression of the Cyclin-D 1 protein in 50 % of tumor cells. At the same time, the structures of meninoteliomatous meningioma showed insignificant nuclear expression of the index of proliferative activity Ki‑67 within 3 % of cell nuclei. The results obtained indicate a high prognostic value of the nuclear expression of the Cyclin-D 1 protein in predicting relapses of meningotheliomatous meningiomas.
About the Authors
I. V. Balyazin-Parfenov
Federal State-Financed Educational Institution of Higher Professional Education “Rostov State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
V. A. Balyazin
Federal State-Financed Educational Institution of Higher Professional Education “Rostov State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
S. S. Todorov
Federal State-Financed Educational Institution of Higher Professional Education “Rostov State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
V. Y. Deribas
Federal State-Financed Educational Institution of Higher Professional Education “Rostov State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
V. E. Khatyushin
Federal State-Financed Educational Institution of Higher Professional Education “Rostov State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
N. R. Saburov
Federal State-Financed Educational Institution of Higher Professional Education “Rostov State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Balyazin-Parfenov I.V., Balyazin V.A., Todorov S.S., Deribas V.Y., Khatyushin V.E., Saburov N.R. On the prediction of postoperative recurrence of meningioma. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2021;13(2):18-23. (In Russ.)
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