Platelet-rich plasma – a new pathogenetic method for the treatment of compression radiculopathy
https://doi.org/10.56618/2071-2693_2025_17_3_130
EDN: HAWVMD
Abstract
INTRODUCTION. The number of surgeries for degenerative-dystrophic lesions of the spine increases every year. However, there are methods of orthobiological therapy that allow avoiding surgeries and their consequences in patients with lumbar radiculopathy due to disc herniation.
AIM. To evaluate the efficacy and safety of platelet rich plasma (PRP) injections in patients with compression radiculopathy due to lumbar disc herniation, and to evaluate the effect of PRP on the resorption of lumbar disc herniation.
MATERIALS AND METHODS. The study included 100 patients with lumbar radiculopathy due to disc herniation. The efficacy of transforaminal PRP injections at the level of the herniation was assessed. Pain syndrome was assessed using the Numeric Rating Scale (NRS), and quality of life was assessed using the Oswestry Disability Index (ODI). The size of the disc herniation was assessed using MRI data before treatment and 4 months after the PRP therapy course.
RESULTS. The CRS index decreased by 85 %, the quality of life index improved by 67,6 %, and disc herniation resorption was observed in 82 % of patients.
CONCLUSION. PRP therapy is an effective and safe method for treating patients with lumbar radiculopathy associated with intervertebral disc herniation, and promotes accelerated resorption of intervertebral disc herniation as the main pathogenetic factor in compression radiculopathy, i.e. it can be used as a pathogenetic therapy for this pathology.
About the Authors
A. A. Shatokhin
Stavropol State Medical University
Russian Federation
Russian Federation
Anton A. Shatokhin – Postgraduate Student at the Department of Neurology, Neurosurgery and Medical Genetics
310 Mira street, Stavropol, 355017
I. A. Vyshlova
Stavropol State Medical University
Russian Federation
Russian Federation
Irina A. Vyshlova – Dr. of Sci. (Med.), Professor at the Department of Neurology, Neurosurgery and Medical Genetics
310 Mira street, Stavropol, 355017
S. M. Karpov
Stavropol State Medical University
Russian Federation
Russian Federation
Sergey M. Karpov – Dr. of Sci. (Med.), Full Professor, Head at the Department of Neurology, Neurosurgery and Medical Genetics
310 Mira street, Stavropol, 355017
References
1. Parfenov V. A., Yakhno N. N., Davydov O. S. et al. Discogenic lumbosacral radiculopathy. Recommendations of the Russian Association for the Study of Pain (RSSP). Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):15–24. (In Russ.). Doi: 10.14412/2074-2711-2020-4-15-24.
2. Benoist M. The natural history of lumbar disc herniation and radiculopathy. Joint Bone Spine. 2002;69(2):155–160. Doi: 10.1016/S1297-319X(02)00385-8.
3. Benson R. T., Tavares S. P., Robertson S. C., Sharp R., Marshall R. W. Conservatively treated massive prolapsed discs: a 7-year follow-up. Ann R Coll Surg Engl. 2010;92(2):147–153. Doi: 10.1308/003588410X12518836438840.
4. Macki M., Hernandez-Hermann M., Bydon M., Gokaslan A., McGovern K., Bydon A. Spontaneous regression of sequestrated lumbar disc herniations: literature review. Clin Neurol Neurosurg. 2014;(120):136–141. Doi: 10.1016/j.clineuro.2014.02.013.
5. Orief T., Orz Y., Attia W., Almusrea K. Spontaneous resorption of sequestrated intervertebral disc herniation. World Neurosurg. 2012;77(1):146–152. Doi: 10.1016/j.wneu.2011.04.021.
6. Zhong M., Liu J. T., Jiang H., Mo W., Yu P. F., Li X. C., Xue R. R. Incidence of spontaneous resorption of lumbar disc herniation: a meta-analysis. Pain Physician. 2017;20(1):e45–e52.
7. Lubkowska A., Dolegowska B., Banfi G. Growth factor content in PRP and their applicability in medicine. J Biol Regul Homeost Agents. 2012;26(2suppl 1):3S–22S.
8. Mussano F., Genova T., Munaron L., Petrillo S., Erovigni F., Carossa S. Cytokine, chemokine, and growth factor profile of platelet-rich plasma. Platelets. 2016;27(5):467– 471. Doi: 10.3109/09537104.2016.1143922.
9. Yum J. I., De Luigi A. J., Umphrey G. L., Ganter B. K., Yoo M. Platelet-Rich Plasma Treatment for the Lumbar Spine: A Review and Discussion of Existing Gaps. Pain Physician. 2024;27(5):283–302.
10. Rawson B. Platelet-rich plasma and epidural platelet lysate: Novel treatment for lumbar disk herniation. J. Am. Osteopath. Assoc. 2020;(120):201–207. Doi: 10.7556/jaoa.2020.032.
11. Gupta A., Chhabra H. S., Singh V., Nagarjuna D. Lumbar Transforaminal Injection of Steroids versus Platelet-Rich Plasma for Prolapse Lumbar Intervertebral Disc with Radiculopathy: A Randomized Double-Blind Controlled Pilot Study. Asian Spine J. 2024;18(1):58–65. Doi: 10.31616/asj.2023.0115.
12. Guerrero-Molina A. L., Cruz-Álvarez M. G., Tenopala-Villegas S. Revisión bibliográfica de la eficacia del tratamiento con plasma rico en plaquetas en hernia de disco lumbar [Bibliographic review of the efficacy of platelet-rich plasma treatment in lumbar disc herniation]. Acta Ortop Mex. 2023;37(5):290–295.
13. Tkachev A. M., Epifanov A. V., Akarachkova E. S., Smirnova A. V., Iliushin A. V., Archakov D. S. Pathophysiologic aspects of resorption of intervertebral disk hernia. Consilium Medicum. 2019;21(2):59–63. (In Russ.). Doi: 10.26442/20751753.2019.2.180147.
14. Sanginov A. J., Isakov I. D., Akhmetyanov Sh. A., Peleganchuk A. V. Resorption of lumbar disc herniations: a non-systematic literature review. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2024;21(1):55–62. (In Russ.). Doi: 10.14531/ss2024.1.5562.
15. Dhurat R., Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author’s perspective. J Cutan Aesthet Surg. 2014;7(4):189–197. Doi: 10.4103/0974-2077.150734.
Review
For citations:
Shatokhin A.A., Vyshlova I.A., Karpov S.M. Platelet-rich plasma – a new pathogenetic method for the treatment of compression radiculopathy. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2025;17(3):130-138. (In Russ.) https://doi.org/10.56618/2071-2693_2025_17_3_130. EDN: HAWVMD
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