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Analysis of the relationship between 18-fdg metabolism in brain tissue, emotional status and life quality in patients with chronic cerebral ischemia

Abstract

   Relevance. Comparison of the data on brain metabolism and the clinical picture of CCI against the background of pathological changes in the brain will make it possible to move to a new level of understanding of the essence of the pathological process, deepen knowledge about the pathogenesis of cerebrovascular diseases and determine the ways of targeted therapeutic and prophylactic effects.

   Purpose of the study. To perform clinical and neuroimaging comparison of the state of brain metabolism, cognition and emotional disorders in patients with chronic cerebral ischemia.

   Material and methods. An open, single-center, uncontrolled study was conducted with the inclusion of 36 patients with CCI, including 4 men and 31 women aged 50 to 88 years (average age 66 ± 4.8 years). Instrumental examination – triplex angioscanning of the vessels of the head and neck. The clinical evaluation included collection of neurological complaints, medical history, and neurological examination. Higher mental functions were assessed using scale methods. The conducted neuroimaging examination of patients included PET with 18-FDG.

   Results and discussion. According to the degree of accumulation of RFP, the patients were divided into two groups: with normal metabolism (11 patients) and with reduced metabolism (24 patients). In the group with hypometabolism, the appearance of focal neurological symptoms was noted. The data of comparative analysis on the scales show that in the group with normal metabolism, patients show higher indicators of mood stability, are less susceptible to depressive fluctuations, better sleep quality, and less pronounced asthenization. The atherosclerotic changes in the cerebral vessels
revealed in patients using ultrasound angioscanning confirmed the data obtained during the clinical neuropsychological and neuroimaging examination.

   Conclusion. CCI has not only neurological, but also a wide range of psychiatric manifestations: from mild – asthenic, to gross – cognitive impairment. Patients at the initial stages do not realize the problem, find themselves out of observation, do not receive proper treatment, which can lead to an increase in cognitive deficit, a decrease in the quality of life, and social functioning.

About the Authors

M. L. Pospelova
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

Maria L. Pospelova

St. Petersburg



D. V. Ryzhkova
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

Darya V. Ryzhkova

St. Petersburg



T. M. Alekseeva
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

Tatiana M. Alekseeva

St. Petersburg



A. A. Mikhalicheva
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

Anna A. Mikhalicheva

St. Petersburg



M. I. Kachkaeva
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

St. Petersburg



I. K. Ternovykh
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

Ivan K. Ternovykh

St. Petersburg



Yu. F. O. Musaev
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

St. Petersburg



E. A. Mokin
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

St. Petersburg



R. M. Elizarov
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

St. Petersburg



A. M. Makhanova
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation

Albina M. Makhanova

St. Petersburg



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Review

For citations:


Pospelova M.L., Ryzhkova D.V., Alekseeva T.M., Mikhalicheva A.A., Kachkaeva M.I., Ternovykh I.K., Musaev Yu.F., Mokin E.A., Elizarov R.M., Makhanova A.M. Analysis of the relationship between 18-fdg metabolism in brain tissue, emotional status and life quality in patients with chronic cerebral ischemia. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2021;13(4):72-77. (In Russ.)

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ISSN 2071-2693 (Print)