Surgical outcomes in drug resistant epilepsy associated with hippocampal sclerosis

PURPOSE OF THE STUDY: to evaluate the results of surgical treatment in adult patients with drug resistant epilepsy associated with mesial temporal sclerosis.

MATERIALS AND METHODS. Fifty-one patients with mesial temporal sclerosis and drug resistant epilepsy were examined and surgically treated at Federal State Budgetary Institution “Scientific Center of Neurology” during the period from March 2018 to May 2022.

RESULTS. Mean patient age was 33,5±9,3 years, mean epilepsy duration was 21,4±11,3лет; there were 32 cases of dominant and 19 cases of subdominant mesial temporal sclerosis. The percentage of seizure free outcomes (Engel class IA) was 76, 67, 52 and 35 % at 6 months, 1 year, 2 years and 3 years after surgery. We observed no significant neurological impairment in our patients postsurgically.

CONCLUSION. The results of this study show high efficacy and safety profile of surgical treatment in adult patients with drug resistant epilepsy associated with mesial temporal sclerosis.

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