Arteriovenous cerebral blood flow uncoupling in TBI: observational CT perfusion study.
https://doi.org/10.56618/2071-2693_2025_17_3_54
EDN: FOLXVE
Abstract
AIM. To investigate correlations between intracranial pressure and arterial and venous cerebral blood flow (CBF) in patients with moderate to severe traumatic brain injury (TBI) and after surgical removal of intracranial hematomas.
MATERIALS AND METHODS. Patients with moderate to severe TBI (53 women; 74 men) were divided into 3 groups: group 1 (moderate TBI), group 2 (severe TBI without surgery), and group 3 (severe TBI after surgery). All patients underwent perfusion computed tomography (PCT), which was used to measure arterial and venous cerebral blood flow (CBF) in the supraclinoid sections of both internal arteries (CBF in ICA) and in the superior sagittal sinus (CBF in SSS). The obtained data were analyzed using parametric and nonparametric statistics. The significance level was accepted as p<0.05.
RESULTS. In Group I, the left and right ICA CBFs correlated significantly with each other (p<0.0001) and with the SCD CBF (p=0.048). In Group II, the left and right ICA CBFs also correlated (P<0.0000001), but not with the SSS CBF. In Group III, the ICA CBF on the side of the removed hematoma did not significantly differ from the contralateral ICA CBF (P=0.680) and did not correlate with the SSS CBF.
CONCLUSION. Increasing TBI severity is accompanied by arterial and venous CBF uncoupling in the supratentorial vessels. Further research is needed to identify the mechanisms underlying this dissociation.
Supporting agencies: The work was supported by a grant from the Russian Science Foundation No. 24-45-00010.
About the Authors
A. V. Kivenko
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Anastasia V. Kivenko – Student at the Department of Nervous Diseases
10/1 Minin and Pozharsky square, Nizhny Novgorod, 603005
R. Adibekov
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Rakhmonali Adibekov – Student at the Department of Nervous Diseases
10/1 Minin and Pozharsky square, Nizhny Novgorod, 603005
A. A. Lazarev
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Alexander A. Lazarev – Assistant at the Department of Nervous Diseases
10/1 Minin and Pozharsky square, Nizhny Novgorod, 603005
G V. Kalentyev
City Clinical Hospital No. 10 of the Kanavinsky District of Nizhny Novgorod
Russian Federation
Russian Federation
Georgy V. Kalentyev – Doctor
43 Chongarskaya street, Nizhny Novgorod, 603011
K. A. Trofimova
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Ksenia A. Trofimova – Student at the Department of Nervous Diseases
10/1 Minin and Pozharsky square, Nizhny Novgorod, 603005
A. O. Trofimov
Privolzhsky Research Medical University;
Saratov State Research University named after N. G. Chernyshevsky
Russian Federation
Russian Federation
Alexey O. Trofimov – Cand. of Sci. (Med.), Associate Professor at the Department of Nervous Diseases, Privolzhsky Research Medical University; Senior Researcher, Saratov State Research University named after N. G. Chernyshevsky
10/1 Minin and Pozharsky square, Nizhny Novgorod, 603005;
83 Astrakhanskaya street, Saratov, 410012
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Review
For citations:
Kivenko A.V., Adibekov R., Lazarev A.A., Kalentyev G.V., Trofimova K.A., Trofimov A.O. Arteriovenous cerebral blood flow uncoupling in TBI: observational CT perfusion study. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2025;17(3):54-59. (In Russ.) https://doi.org/10.56618/2071-2693_2025_17_3_54. EDN: FOLXVE
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